Confirmation of central versus peripheral mast cell manipulations and effects of mast cell manipulations on microglia. Confirmation of central versus peripheral.

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Confirmation of central versus peripheral mast cell manipulations and effects of mast cell manipulations on microglia. Confirmation of central versus peripheral mast cell manipulations and effects of mast cell manipulations on microglia. A, B, Compound 48/80 treatment in vivo (intracerebroventricularly) led to significant increases in percentage of degranulated mast cells in the POA of females on P2 (full bars indicate total number of mast cells, shaded bars indicate number of degranulated mast cells (A), as well as increased histamine turnover in the POA as measured by LC-MS/MS (B). C, Treatment with compound 48/80 (4880) did not change the proportion of degranulated mast cells in the spleen. D, E, Treatment of females with the mast-cell-degranulating agent compound 48/80 increased the proportion of microglia in an ameboid state in females to male levels. F, G, Treatment of maternal dams with the mast cell stabilizer ketotifen (keto) in their drinking water led to significant decreases in the percentage of degranulated mast cells in the POA of offspring of both sexes (F) and decreased the proportion of microglia in the ameboid state in males to the level seen in females (G). *p < 0.05, **p < 0.01, ***p < 0.001, ∧p < 0.05 for percentage degranulated mast cells. Group sizes: A: ♀V, n = 4; ♀4880 n = 5; B, all groups, n = 5; C, ♂V, n = 5; ♀V, n = 3, ♀4880, n = 4. D, ♂V, n = 7; ♀V, n = 5; ♀4880 n = 6; F, G, ♂V, n = 5; ♂, keto, n = 5; ♀V, n = 5; ♀, keto, n = 6. Kathryn M. Lenz et al. J. Neurosci. 2018;38:8044-8059 ©2018 by Society for Neuroscience