Astroglial activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

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SPINAL CORD Will Kleinelp Associate Professor Dept of Biology.

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Spinal Cord Chapter 13.

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SPINAL CORD Will Kleinelp Associate Professor Dept of Biology.

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Astroglial activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal cord levels (between both scapulae). Astroglial activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal cord levels (between both scapulae). A, C, Immunohistochemistry of the cervical and lumbar spinal cord for astroglia stained with anti-S100β antibody in mice with asthma (A) or atopic dermatitis (C). Scale bars, 100 μm. B, C, Comparison of astroglial density was made between the cervical and lumbar spinal cord levels in asthma model mice (B) and atopic dermatitis model mice (D). E, F, Astroglial density according to the location of the spinal cord in PBS-pretreated and O+A-pretreated asthma model mice (E) and atopic dermatitis model mice (F). Unlike microglia, astroglia density is similar between the anterior and posterior regions in both models. a, Anterior region; p, posterior region; PBS, control mice; O+A, bronchial asthma mice. *p < 0.05 (Tukey's post test after one-way ANOVA). **p < 0.01 (Tukey's post test after one-way ANOVA). ***p < 0.001 (Tukey's post test after one-way ANOVA). Ryo Yamasaki et al. J. Neurosci. 2016;36:11929-11945 ©2016 by Society for Neuroscience