Prakash K. Pandalai, MD, Jefferson M. Lyons, MD, Jodie Y

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Role of the β-adrenergic receptor kinase in myocardial dysfunction after brain death Prakash K. Pandalai, MD, Jefferson M. Lyons, MD, Jodie Y. Duffy, PhD, Kelly M. McLean, MD, Connie J. Wagner, BS, Walter H. Merrill, MD, Jeffrey M. Pearl, MD, Shahab A. Akhter, MD The Journal of Thoracic and Cardiovascular Surgery Volume 130, Issue 4, Pages 1183-1189 (October 2005) DOI: 10.1016/j.jtcvs.2005.06.034 Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Left ventricular preload recruitable stroke work (PRSW) at baseline and after sham operation or induction of brain death. *P < .05 versus sham operation and baseline drain death. #P = not significant versus baseline sham operation. Diamonds, Sham operation (n = 8); squares, BD (n = 8). B, Left ventricular dP/dTmin at baseline and after sham operation or induction of BD. *P < .05 versus sham operation. #P < .05 versus baseline BD. Diamonds, Sham operation (n = 8); squares, BD (n = 8). The Journal of Thoracic and Cardiovascular Surgery 2005 130, 1183-1189DOI: (10.1016/j.jtcvs.2005.06.034) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Myocardial sarcolemmal membrane adenylate cyclase activity 6 hours after sham operation or induction of BD. ISO, 10-4 mol/L isoproterenol; NaF, 50 mmol/L sodium fluoride. Open columns, Sham operation (n = 8); filled columns, BD (n = 8). *P < .03 versus sham operation. cAMP, Cyclic adenosine monophosphate. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 1183-1189DOI: (10.1016/j.jtcvs.2005.06.034) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Myocardial sarcolemmal membrane β-adrenergic receptor (βAR) density at 6 hours after sham operation (Sh) or induction of brain death (BD; n = 8 in each group performed in triplicate). P = not significant between groups. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 1183-1189DOI: (10.1016/j.jtcvs.2005.06.034) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Myocardial sarcolemmal membrane β-adrenergic receptor kinase (βARK1) protein expression at 6 hours after sham operation (Sh) or induction of brain death (BD; n = 8 in each group). *P < .05 versus sham operation. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 1183-1189DOI: (10.1016/j.jtcvs.2005.06.034) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Myocardial sarcolemmal membrane G protein–coupled receptor kinase activity at 6 hours after sham operation (Sh) or induction of brain death (BD; n = 8 in each group). *P < .02 versus sham operation. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 1183-1189DOI: (10.1016/j.jtcvs.2005.06.034) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions