Fig. 1 Lkb1 loss leads to a complex neural crest phenotype.

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Presentation transcript:

Fig. 1 Lkb1 loss leads to a complex neural crest phenotype. Lkb1 loss leads to a complex neural crest phenotype. (A) Representative picture of a male animal with homozygous Lkb1 ablation (Lkb1 cKO) using the Tyr::Cre driver, which typically displays coat color hypopigmentation. (B) Kaplan-Meier graph comparing the survival of Lkb1-knockout (cKO), heterozygous (Htz), and WT male littermates. The number of animals is indicated above the curves. (C) Lkb1 cKO mice rapidly lose weight compared to WT littermates (weight curves for cKO indexed to WT). (D) cKO mice develop a progressive intestinal pseudo-obstruction as shown at P21 (middle) by empty colon (Co) and atrophy of the cecum (Ce) and at adulthood (bottom) with atrophy of the stomach (St, dotted arrow), dilation of the small intestine (Int, arrow head), hypertrophy of the cecum (arrow), and colon constriction (empty arrow) compared to WT (top) (n ≥ 8 mice per group). (E) Loss of hind limb extension reflex in Lkb1 cKO P21 mice compared to control animal (WT) manifested by hind limb clenching when lifted by the tail. (F) Appearance of sciatic nerves from control and Lkb1 cKO mice at P21 showing myelinization defects in the mutant. Photo credits: Sakina Torch and Chantal Thibert, University Grenoble Alpes. Anca G. Radu et al. Sci Adv 2019;5:eaau5106 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).