Cardioprotection by sevoflurane against reperfusion injury after cardioplegic arrest in the rat is independent of three types of cardioplegia D. Ebel,

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Cardioprotection by sevoflurane against reperfusion injury after cardioplegic arrest in the rat is independent of three types of cardioplegia D. Ebel, B. Preckel, A. You, J. Mu¨llenheim, W. Schlack, V. Tha¨mer British Journal of Anaesthesia Volume 88, Issue 6, Pages 828-835 (June 2002) DOI: 10.1093/bja/88.6.828 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Experimental programme and treatment of the seven study groups (UW, University of Wisconsin solution; NTK, Bretschneider’s cardioplegia; STH, St Thomas’ Hospital solution). British Journal of Anaesthesia 2002 88, 828-835DOI: (10.1093/bja/88.6.828) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 Left ventricular developed pressure (LVDP, top), left ventricular end‐diastolic pressure (LVEDP, middle), and coronary flow (CF, bottom). In the UW group, the hearts were arrested with cold UW solution at the beginning of the 30 min ischaemia. The hearts in the UW+Sevo group additionally received sevoflurane during the first 15 min of reperfusion. Data are mean (sem). †P<0.05 vs control. British Journal of Anaesthesia 2002 88, 828-835DOI: (10.1093/bja/88.6.828) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 3 Left ventricular developed pressure (LVDP, top), left ventricular end‐diastolic pressure (LVEDP, middle), and coronary flow (CF, bottom). The hearts in the HTK group were protected against ischaemic damage by cardioplegic arrest with Bretschneider’s solution. In the HTK+Sevo group, sevoflurane was administered additionally during early reperfusion. Data are mean (sem). *P<0.05 HTK vs HTK+Sevo; †P<0.05 vs control. British Journal of Anaesthesia 2002 88, 828-835DOI: (10.1093/bja/88.6.828) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 4 Left ventricular developed pressure (LVDP, top), left ventricular end‐diastolic pressure (LVEDP, middle), and coronary flow (CF, bottom). In the STH group, hearts cardioplegic arrest was performed by administration of St Thomas’ Hospital solution at the beginning of ischaemia. In the STH+Sevo group, the hearts additionally received sevoflurane during early reperfusion. Data are mean (sem). *P<0.05 STH vs STH+Sevo; †P<0.05 vs control. British Journal of Anaesthesia 2002 88, 828-835DOI: (10.1093/bja/88.6.828) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 5 The infarct size in per cent of right and left ventricle. Data are mean (sem). *P<0.05 cardioplegia vs cardioplegia+sevoflurane; †P<0.05 vs control. British Journal of Anaesthesia 2002 88, 828-835DOI: (10.1093/bja/88.6.828) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions