Fig. 4 Click Chips combined with RT-ddPCR analysis can be used to monitor dynamic changes in CTC count and CTC-derived ALK/ROS1 rearrangements in patients.

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Fig. 4 Click Chips combined with RT-ddPCR analysis can be used to monitor dynamic changes in CTC count and CTC-derived ALK/ROS1 rearrangements in patients with NSCLC over the course of crizotinib (ALK/ROS1-TKI) treatments. Click Chips combined with RT-ddPCR analysis can be used to monitor dynamic changes in CTC count and CTC-derived ALK/ROS1 rearrangements in patients with NSCLC over the course of crizotinib (ALK/ROS1-TKI) treatments. (A) Schematic illustrating the general workflow developed for conducting CTC enumeration and CTC-based ALK/ROS1 rearrangement quantification. (B) The dynamic changes (0 to 129 days) of CTC counts and rearranged ALK transcripts (per 2 ml of blood) observed for a patient with NSCLC harboring the EML4-ALK rearrangement (A07) before and after crizotinib treatment. (C) CT images of patient A07 taken at days 0, 77, and 129, after crizotinib treatment. (D) Representative fluorescent micrographs of CTCs (DAPI+/CK+/CD45–) captured from patient A07’s blood samples using Click Chips. (E) Dynamic change (0 to 75 days) of CTC counts and rearranged ROS1 transcripts (per 2 ml of blood) observed for a patient with NSCLC with the CD74-ROS1 rearrangement (R05) before and after crizotinib treatment. (F) Chest CT scans of patient R05 taken at days 0, 30, and 75 after crizotinib treatment. (G) Representative fluorescent micrographs of the CTC populations obtained from patient R05. Jiantong Dong et al. Sci Adv 2019;5:eaav9186 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).