Fig. 1 Schematic illustrating the combined use of bioorthogonal ligation (i.e., the reaction between Tz and TCO) and disulfide cleavage–driven by DTT to.

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Fig. 1 Schematic illustrating the combined use of bioorthogonal ligation (i.e., the reaction between Tz and TCO) and disulfide cleavage–driven by DTT to enable capture and release of CTCs using Click Chips. Schematic illustrating the combined use of bioorthogonal ligation (i.e., the reaction between Tz and TCO) and disulfide cleavage–driven by DTT to enable capture and release of CTCs using Click Chips. The purified CTCs can then be subjected to RT-ddPCR to detect ALK or ROS1 rearrangements in NSCLC samples with single-molecule precision. cDNA, complementary DNA. Jiantong Dong et al. Sci Adv 2019;5:eaav9186 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).