Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance Unweighted UniFrac principal coordinates analysis.

Slides:

Advertisements

Similar presentations

Individualized pain management plan.

Advertisements

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Reach‐scale conceptual model of the fluvial carbon.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Modeling domain for the main stem of the South Elkhorn.

(a) illuminance measured in the horizontal plane from a typical street light (Phillips Cosmopolis, metal halide lamp). The intensity of light decays rapidly.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Sensitivity analysis of the ISOFLOC model displays.

Isotope‐based Fluvial Organic Carbon (ISOFLOC) Model: Model formulation, sensitivity, and evaluation Model flowchart for ISOFLOC which details inputs,

Evening evapotranspirative cooling in relation to vegetation and urban geometry in the city of Ouagadougou, Burkina Faso Relation between sky view factor.

Matrilin‐2 prevents the TNFα‐induced apoptosis of WB‐F344 cells via suppressing JNK pathway Matrilin‐2 knockdown promotes the apoptosis of WB‐F344 cells.

RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 Knockdown.

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations qRT–PCR analysis of Klf4 during disease progression at.

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy Number of metastatic lung foci in untreated (control) and.

Atrial‐like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial‐selective pharmacology AAP illustrating.

Details of the binding sites of tetracycline and edeine

The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication Representative images of wt and mdi1 ovarioles stained.

Co‐immunoprecipitation of Larp with MDI‐myc in transfected S2 cells

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance ATranscript levels of NOD2 in various tissues.

Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine‐resistant malaria.

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries Global Maps Presenting the Most.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production Representative hematoxylin and eosin (H&E)‐stained sections of perigonadal white.

SORCS1 and SORCS3 control energy balance and orexigenic peptide production A, BBlood glucose (A) and insulin (B) levels after overnight fasting in 9‐month‐old.

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance A–DThe number of ampicillin‐resistant E. coli.

Regional weather and climates of the British Isles ‐ Part 1: Introduction The annual rainfall anomaly (percentage difference from normal) for Western Scotland.

Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells A, BRepresentative immunofluorescence images.

Applications of genome‐scale metabolic reconstructions

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells In vivo imaging of a invCAG‐Luc;Rb1F/F;Trp53F/F chimeric.

Representative electron density maps

Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2 (A) pH dependency of the state 4 respiratory rate: control ▵ and UCP2 mitochondria.

Anthropogenic noise weakens territorial response to intruder's songs

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology Aβ1‐42 induces pore‐like.

Prevalence of women with advanced maternal age by country.

Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death WT and NEDP1 KO HEK 293 cells were transfected with FLAG‐NSUN2.

Model for end‐stage liver disease exception points for treatment‐responsive hepatocellular carcinoma Treatment‐responsive HCC: patient with complete response.

Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases Schematic depiction of modification.

Accuracy of protein allele‐specific expression (pASE) measurements

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution A, BMyo19 levels correlate with the quantity of Miro.

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1 One night after cell purification, CD8+‐depleted PBMCs from.

Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1 One night after cell purification, HLA DR− CD69− CD25− CD4+

Induced chromosome deletions cause hypersociability and other features of Williams–Beuren syndrome in mice Expression of genes measured by real‐time qRT‐PCR.

Structural and functional analysis of the GABARAP interaction motif (GIM) Interaction profile of 30 biotinylated LIR peptides from various proteins against.

APhagocytosis assay of apoptotic or necrotic GFP‐expressing RAW264

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes Western blotting of LC3 in ATG16L1 FL, ΔFBD‐

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention (A) Schematic of the human breast highlighting terminal ductal.

Role of the WNK‐activated SPAK kinase in regulating blood pressure

Mapping the interaction of Snf1 with TORC1 in Saccharomyces cerevisiae

Kinesin‐2 motors adapt their stepping behavior for processive transport on axonemes and microtubules A–CThe movement of single KLP3A/B motors fluorescently.

Annexin A1 attenuates EMT and metastatic potential in breast cancer

Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma Abundance of proteins matching selected subcellular locations.

D‐Aspartate treatment attenuates myelin damage and stimulates myelin repair ALeft: Superimposed single‐cell traces representative of the effect of 10 μM.

Heterogeneity in Δψmit reported by TMRE

Mitochondria are morphologically and functionally heterogeneous within cells Surface‐rendered three‐dimensional reconstructions of cells expressing mito‐DsRed1.

Malaria inflammation by xanthine oxidase‐produced reactive oxygen species A, BMacrophages produce little to no inflammatory cytokines when incubated with.

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance APrincipal coordinates analysis (PCoA) performed.

Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice A–DCholesterol metabolic parameters were.

Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death Western blot analysis of whole‐cell lysates from U2OS WT and NEDP1.

Update of the Scientific Opinion on the risks to plant health posed by Xylella fastidiosa in the EU territory Boxplots for how (a) landscape type, (b)

Cesarean section scar diverticulum evaluation by saline contrast‐enhanced magnetic resonance imaging: The relationship between variable parameters and.

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins The content of p97 and two of its cofactors are induced.

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins Electroporation of DNp97 in TA blocks both denervation.

CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte Live‐cell imaging results showing in vitro.

M‐LDH serves as a sarcolemmal KATP channel subunit essential for cell protection against ischemia The opening of KATP channels and intact activity of M‐LDH.

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress AFilter‐trap binding assays show that the ISR proteins.

Processive movement of single kinesins on crowded microtubules visualized using quantum dots Effect of the mutant E164A on the motility of single quantum.

CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte Relative mRNA copy number dynamics in.

The Escherichia coli RNA polymerase α subunit linker: length requirements for transcription activation at CRP‐dependent promoters Comparison of the effect.

EglN2 associates with the NRF1‐PGC1α complex and controls mitochondrial function in breast cancer A, BqRT–PCR of mRNA from T47D transfected with either.

Imaging Disaster: Puerto Rico through the Eye of Hurricane María

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression Immunoprecipitation of CD147 from RBL.

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression The transmembrane and cytoplasmic regions.

Identification of a novel population of highly cytotoxic c‐Met‐expressing CD8+ T lymphocytes Day 5 c‐Met+ or c‐Met− CD45.2+ Pmel‐1 CTLs treated with either.

Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis RuBisCO initial and total activity in WT and hda14 in low‐light‐treated.

Presentation transcript:

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance Unweighted UniFrac principal coordinates analysis (PCoA) plot illustrating the relative degree that genotype (NOD2−/− versus WT, PCoA1: 28%) and diet (chow versus HFD, PCoA2: 16%) defined the diversity of the microbiota in the cecum. The most abundant bacterial genus are labeled and superimposed on the same PCoA plot. Each small dot is a mouse, and the size of the sphere representing a taxon is proportional to the mean relative abundance of the taxon across all samples. Bar graph showing the relative abundance of phyla from each mouse cecum, where each bar is a separate mouse. Alpha diversity represented by the Shannon index in chow‐fed (n = 6) and HFD‐fed (n = 5) WT and NOD2−/− mice. Values are mean ± SEM. Impact of diet on the Firmicutes/Bacteroidetes ratio in the cecum of chow‐fed (n = 12) and HFD‐fed (n = 10) mice. *Significantly different from chow‐fed mice, P = 0.03. An unpaired t‐test was used. Values are mean ± SEM. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO Mol Med, Volume: 7, Issue: 3, Pages: 259-274, First published: 09 February 2015, DOI: (10.15252/emmm.201404169)