Fig. 1 Responsive lock-and-key microgel particle characterization.

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Fig. 1 Responsive lock-and-key microgel particle characterization. Responsive lock-and-key microgel particle characterization. (A) CLSM micrographs of bowl-shaped composite microgels fluorescently labeled in red (rhodamine dye) used as a lock particle. (B) Key particles consisting of cross-linked PNIPAM microgel particles labeled in green (fluorescein), as imaged by CLSM. Scale bars, 1 μm. (C and D) Hydrodynamic radius and electrophoretic mobility measured as a function of temperature: bowl-shaped lock composite microgel (solid circles) and spherical key microgel particle (solid squares). The measurements cross three regions delimited by the VPT temperature of the lock-and-key particles, TVPT,L and TVPT,K. In region 1 (T < TVPT,K), both particles are swollen. In region 2 (TVPT,K ≤ T ≤ TVPT,L), lock particles are swollen and key particles are collapsed. In region 3 (TVPT,L < T), both particles are collapsed. Adriana M. Mihut et al. Sci Adv 2017;3:e1700321 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).