Divergent effects of the 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness and anti-Müllerian hormone.

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Divergent effects of the 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness and anti-Müllerian hormone concentrations  Roman Pavlik, M.D., Stephanie Hecht, M.D., Robert Ochsenkühn, M.D., Ulrich Noss, M.D., Peter Lohse, M.D., Christian J. Thaler, M.D.  Fertility and Sterility  Volume 95, Issue 7, Pages 2257-2262 (June 2011) DOI: 10.1016/j.fertnstert.2011.03.023 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Scatter plot depicting the correlation between AMH serum concentrations and the numbers of oocytes retrieved (NOR) after controlled ovarian hyperstimulation in 109 MTHFR 677CC (black circle, black regression line), 123 MTHFR 677CT (open squares, black dotted regression line), and 38 MTHFR 677TT (gray triangles, black dashed regression line) patients (r = Spearman’s correlation coefficient). Whereas AMH is significantly correlated with NOR in all MTHFR genotypes, homozygous MTHFR 677TT individuals show significantly fewer NOR for given AMH concentrations than do individuals with the other MTHFR 677 genotypes. Fertility and Sterility 2011 95, 2257-2262DOI: (10.1016/j.fertnstert.2011.03.023) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 AMH serum concentrations with regard to the MTHFR 677C>T genotypes. Box plots show median, interquartile range, outliers, and extreme cases of individual variables; AMH concentrations of MTHFR 677 TT individuals are significantly higher than in MTHFR 677CC (**P<0.002) and in MTHFR 677CT individuals (*P<0.04). Fertility and Sterility 2011 95, 2257-2262DOI: (10.1016/j.fertnstert.2011.03.023) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions