Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased.

Slides:

Advertisements

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Advertisements

Fig. 4 Ballistic simulation of BP FETs.

Fig. 1 TET2 is a coactivator of ERα.

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 1 Map of water stress and shale plays.

Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 3 Electron PSD in various regions.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 2 PCA and ADMIXTURE analysis.

Fig. 6 Comparison of properties of water models.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 5 Conservation of m6A in mammals.

m6A identification method based on m6A sensitive RNA endoribonuclease

Fig. 3 Rotation experiment, setup.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 4 Loss of Zic5 derepresses GLUT1/SLC2A1 gene expression.

Fig. 3 The rs risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs risk enhancer is a hub for intrachromosomal.

Fig. 1 Distribution of total and fake news shares.

Fig. 2 2D QWs of different propagation lengths.

Fig. 6 Zic5 regulates glucose metabolism in a β-catenin/Tcf7l2–dependent manner in HCT116 colon cancer cells. Zic5 regulates glucose metabolism in a β-catenin/Tcf7l2–dependent.

Fig. 6 WPS imaging of different chemical components in living cells.

β-Catenin/Tcf7l2 complex recruits Zic5 to regulate gene expression

Fig. 1 A time-course RNA-seq analysis reveals prominent IRF8 expression in the spinal cord during the recovery phase after SCI. A time-course RNA-seq analysis.

Fig. 1 IDH3α expression is elevated in human-derived gliomas.

Fig. 1 Histograms of the number of first messages received by men and women in each of our four cities. Histograms of the number of first messages received.

Fig. 5 Schematic phase diagrams of Ising spin systems and Mott transition systems. Schematic phase diagrams of Ising spin systems and Mott transition systems.

Fig. 4 Bcl11b regulates expression of key Treg cell genes while suppressing inflammatory and innate genes. Bcl11b regulates expression of key Treg cell.

Fig. 4 OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with different pH. OER performance of ACoO3 (A = Ca, Sr) in alkaline solutions with.

Fig. 1 Average contribution (million metric tons) of seafood-producing sectors, 2009–2014. Average contribution (million metric tons) of seafood-producing.

Fig. 4 The mechanical performances of thermally stable click-ionogels.

Fig. 4 Praying Prophet by Lorenzo Monaco: Mapping lake pigments and associated substrate. Praying Prophet by Lorenzo Monaco: Mapping lake pigments and.

Fig. 3 Abundance for all OR-expressing OSN subtypes across mammalian evolution. Abundance for all OR-expressing OSN subtypes across mammalian evolution.

Fig. 4 Visualization of complex loop motions by 1-μs MD trajectories.

Fig. 3 Production of protein and Fe(II) at the end of growth correlated with increasing concentrations of ferrihydrite in the media that contained 0.2.

Fig. 1 Deficient CD73 and CD39 expressions and extracellular adenosine concentration in BM of OVX animals. Deficient CD73 and CD39 expressions and extracellular.

Fig. 4 Differential histone modifications at promoters in various brain cell populations. Differential histone modifications at promoters in various brain.

Fig. 4 Adenosine A2BR signaling promote osteogenic and inhibit osteoclast differentiation in vitro. Adenosine A2BR signaling promote osteogenic and inhibit.

Fig. 1 Global occurrences of hydraulic fracturing–induced seismicity and potential models. Global occurrences of hydraulic fracturing–induced seismicity.

Fig. 2 Top 10 countries, ecoregions, conservation hotspots, and KBAs with the largest area of restoration hotspots. Top 10 countries, ecoregions, conservation.

Fig. 5 Comparison of the liquid products generated from photocatalytic CO2 reduction reactions (CO2RR) and CO reduction reactions (CORR) on two catalysts.

Fig. 4 BS-SEM images, ternary diagrams, and phase maps for the text and reverse sides of the TS. BS-SEM images, ternary diagrams, and phase maps for the.

Fig. 1 Location of the Jirzankal Cemetery.

Fig. 4 CO2 emission changes triggered by the JJJ clean air policy.

Fig. 2 Simulations of possible doping positions and band structures.

Fig. 4 Phase diagram showing significant order parameters ∣pk∣ versus T and wc. Phase diagram showing significant order parameters ∣pk∣ versus T and wc.

Multiplexed four- and eight-channel devices for rapid processing

Fig. 2 Mean field results. Mean field results. (A) Solutions P(x) to Eq. 4 for a range of T and wc = (B) Modulus ∣pk∣ of order parameters versus.

Fig. 3 Comparisons of NDVI trends over the globally vegetated areas from 1982 to Comparisons of NDVI trends over the globally vegetated areas from.

Fig. 1 Schematic depiction of a paradigm for rapid and guided discovery of materials through iterative combination of ML with HiTp experimentation. Schematic.

Fig. 3 Electrochemical performances of symmetric cells using control Li and composite Li electrodes. Electrochemical performances of symmetric cells using.

Fig. 4 Mapping of abundance of the most dominant bacterial and archaeal phyla across France. Mapping of abundance of the most dominant bacterial and archaeal.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 4 Single-particle contact angle measurements.

Fig. 3 Supraballs and films assembled from binary 219/217nm SPs/SMPs.

Fig. 2 Supraballs and films from binary SPs.

Fig. 3 Performance of the generative model G, with and without stack-augmented memory. Performance of the generative model G, with and without stack-augmented.

Fig. 4 Behavior of resistance peak near density nm = 5.

Fig. 2 Comparison between the different reflective metasurface proposals when θi = 0° and θr = 70°. Comparison between the different reflective metasurface.

Fig. 3 Rural-urban gap of per capita income in China from 1978 to Rural-urban gap of per capita income in China from 1978 to The income of.

Fig. 3 Gene expression analysis in 48-plex drug treatment experiments.

Fig. 4 Effects of individual picosecond and microsecond pulses.

Fig. 2 hTERT induces expression of heat shock protein genes through HSF1 and interacts with Hsp70-1. hTERT induces expression of heat shock protein genes.

Fig. 3 Calculated electronic structure of ZrCoBi.

Fig. 5 Enhancers and super-enhancers identified in various brain cell populations. Enhancers and super-enhancers identified in various brain cell populations.

Fig. 1 Completely derived from natural wood, nanowood with hierarchically aligned cellulose nanofibrils can be used as an anisotropic super thermal insulator.

Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. TH17 cell differentiation was severely impaired in Cxxc1-deficient mice.

Fig. 3 4n hybrids undergo bipolar and tripolar mitosis.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

Presentation transcript:

Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. (A) Generation of Zic5 KO HCT116 cells by CRISPR-Cas9. (B) RNA-seq track to show the complete KO of Zic5 in C16 and C18 clones. (C) Immunofluorescence showing the cellular morphology of Zic5 WT and KO HCT116 cells by F-actin staining. (D) Hierarchical clustering analysis and corresponding heat map of differentially expressed genes in HCT116 Zic5 WT and KO cells. The color scale bar indicates the fold change ranges for the comparisons (ratios) indicated on the top of the heat map. (E) Effects of Zic5 KO on gene expression induced by three different conditions. 5-FU, 5-fluorouracil; DAPI, 4′,6-diamidino-2-phenylindole. Zibo Zhao et al. Sci Adv 2019;5:eaax0698 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).