Stanley Nattel JACEP 2017;3:

Slides:

Advertisements

Similar presentations

Signal Transduction II Transduction Proteins & Second Messengers.

Advertisements

Basic Concepts of Metabolism

Signal Transduction Biochemistry – February 23, 2005 Chapter 12 – parts 12.3, 12.4.

CGMP Intracellular Signal cGMP is made from GTP by the enzyme gaunylyl cyclase. Atrial natriuretic peptide and nitric oxide function through this Signal.

Gene Transcription G0G0 G1G1 Priming S G2G2 M Cell Cell Cycle Growth Factors + Growth Factors & Cell Cycle Receptors.

Cytokines, Growth Factors and Hormones SIGMA-ALDRICH.

Signal Transduction HLA-DR stimulus specific receptor signal transductiontranscription translation proteins Receptor associating proteins Protein kinease.

Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: ACCF/AHA 2009 Expert Consensus Document on Pulmonary.

Dr Fatahiya Kashif Signal transduction. Dr Fatahiya Kashif Signal transduction.

Volume 56, Issue 4, Pages (October 1999)

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP CHEST

The JAK-STAT signaling system represents a series of reactions that take place when a hormone binds a receptor that uses this system. While the hormone.

Advances in Molecular Biology of Lung Disease

Introduction to Receptors

Intercellular Communication

Figure. Schematic illustration on chitotriosidase (CHIT1) regulation of TGF-β pathway. CHIT1 enhances the effect of TGF-β through the induction of TGF-β.

by Rogelio Zamilpa, and Merry L. Lindsey

The “Modern” View of Heart Failure

Figure 4. Two Intracellular Signaling Cascades Implicated in Chemosensory Transduction(A) Diagram of cyclic nucleotide signaling in the transduction compartment.

Figure 2 Inflammatory pathways affecting hepatic insulin resistance

Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy Arturo.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Naoto Fujiwara, Scott L. Friedman, Nicolas Goossens, Yujin Hoshida

Innate immune-signaling cascades and evidence for upregulation in brain following AIE exposure. Innate immune-signaling cascades and evidence for upregulation.

Figure 3 Extracellular stimuli to HSC activation

Endothelin-1: a key pathological factor in pre-eclampsia?

You have identified a novel cytoplasmic protein

Potential pathways directly linking obesity with cancer.

Figure 1 The role of GPCRs in the regulation of human physiology

Primary Immunodeficiencies

Signal Transduction Through the Epidermal Growth Factor Receptor

Obstructive nephropathy: Insights from genetically engineered animals

Figure 1 Overview of canonical TGF-β/Smad signalling in tissue fibrosis Figure 1 | Overview of canonical TGF-β/Smad signalling in tissue fibrosis. Once.

Nat. Rev. Rheumatol. doi: /nrrheum

Mechanisms of mast cell signaling in anaphylaxis

Tammo Ostendorf, Peter Boor, Claudia R.C. van Roeyen, Jürgen Floege

Figure 3 Integrative signalling networks enable interactions

Figure 4 Potential therapeutic strategies to inhibit TGF-β1/Smad-induced tissue fibrosis Figure 4 | Potential therapeutic strategies to inhibit TGF-β1/Smad-induced.

BDNF and insulin signaling pathways activated by phytochemicals.

Nat. Rev. Nephrol. doi: /nrneph

Michael G. Katz, MD, PhD, Elizabeth Brandon-Warner, PhD, Anthony S

Schematic view of Trk receptors signalling, showing the three major pathways involved in cell differentiation and survival. Schematic view of Trk receptors.

Figure 1 The major structure of kisspeptins in humans, the peptides encoded by theKISS1gene. All kisspeptins are the products generated by the cleavage.

Figure 1 The insulin signalling pathway

Nat. Rev. Cardiol. doi: /nrcardio

Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance Sergei A. Grando, Mark R. Pittelkow, Karin U.

TCF7L2 ChIP-seq in HCT116 cells.

Enyu Imai, Hideaki Nakajima, Jun-Ya Kaimori Kidney International

Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis.

Michael G. Katz, MD, PhD, Anthony S. Fargnoli, PhD, Andrew P

BRAF Alterations as Therapeutic Targets in Non–Small-Cell Lung Cancer

Figure 4 Mechanisms of leptin function on kidney injury

Volume 81, Issue 5, Pages (March 2012)

Chapter 14 Blood Pressure – Regulation and Pathology

Biological network analysis of differentially expressed proteins in both pancreatic cancer and chronic pancreatitis using MetaCore mapping tool. Biological.

Live Longer sans the AT1A Receptor

Volume 73, Issue 1, Pages 5-7 (January 2008)

Signal Transduction Through the Epidermal Growth Factor Receptor

Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury Yasuhiko Yamamoto, Hiroshi.

Yan Feng, MD, Praveena S. Thiagarajan, PhD, Patrick C. Ma, MD

Key mechanistic pathways in DKD

Figure 4 Bile-acid-induced TGR5 signalling pathways in macrophages

Smad3 and Extracellular Signal-Regulated Kinase 1/2 Coordinately Mediate Transforming Growth Factor-β-Induced Expression of Connective Tissue Growth Factor.

Platelet-derived growth factor (PDGF) signalling pathway.

Volume 76, Issue 5, Pages (September 2009)

Primary immunodeficiencies: A rapidly evolving story

Volume 56, Issue 4, Pages (October 1999)

Yiannis S. Chatzizisis et al. JACC 2007;49:

Signaling pathways of galanin receptors.

Airway smooth muscle: A modulator of airway remodeling in asthma

Presentation transcript:

Stanley Nattel JACEP 2017;3:425-435 Major Profibrotic Signaling Pathways Involved in Atrial Fibrosis Pathways are interlinked, and some produce positive feedback that is important in fibrosis. αβ = integrin receptor α and β subunits; AngII = angiotensin-II; AP = activator protein; AT1R = angiotensin type 1 receptor; CTGF = connective tissue growth factor; DAG = diacylglycerol; ER = endoplasmic reticulum; ERK1/2 = extracellular signal-related kinase–1/2; Grb2 = growth-factor receptor-binding protein 2; IP3 = inositol-1,4,5-trisphosphate; JAK = Janus kinase; JNK = c-Jun N-terminal kinase; MAPK = mitogen-activated protein kinase; MMP = matrix metalloproteinase; NADPH = nicotine adenine dinucleotide-phosphate; NF-κB = nuclear factor-kappa B; PKC = protein kinase C; PDGF = platelet-derived growth factor; PDGFR = platelet-derived growth factor receptor; PIP2 = phosphatidylinositol bisphosphate; PLC = phospholipase C; ROS = reactive oxygen species; Shc = src homologous and collagen protein; SMA = smooth muscle actin; SMAD = sma- and mad-related proteins; SOS = son of sevenless protein; Src = sarcoma proto-oncogene tyrosine kinase; STAT = signal transducers and activators of transcription; TAK1 = TGFβ1-activated kinase–1; TF = transcription factor; TGFβ = transforming growth factor beta; TGF-βR = transforming growth factor-beta receptor; TIMP = tissue inhibitor of matrix metalloproteinase; TSS = transcriptional start site. Stanley Nattel JACEP 2017;3:425-435 2017 American College of Cardiology Foundation