TBS- and HFS activate different signaling pathways.

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TBS- and HFS activate different signaling pathways. TBS- and HFS activate different signaling pathways. A, Immunohistochemical staining of p-ERK 10 min after TBS and HFS in WT mice. Scale bar, 50 μm. B, Quantification of p-ERK fluorescence intensity in control, TBS, and HFS. n = 4 slices from 3 animals in each group. *p < 0.05, compared with Ctrl (one-way ANOVA followed by Bonferroni test). C, Western blots for SCOP, p-AKT and AKT, and p-ERK and ERK 10 min following TBS or HFS in CA1 mini-slices. D, Quantitative data for SCOP, p-Akt/Akt, and p-ERK/ERK. Data are means ± SEM of 3 experiments. *p < 0.05, compared with Ctrl (one-way ANOVA followed by Bonferroni test). E, TBS, but not HFS, induced ERK activation in WT, but not in calpain-1 KO, mice. F, Quantification data for p-ERK levels. n = 4. *p < 0.05, compared with Ctrl (one-way ANOVA followed by Bonferroni test). G, H, Effect of the MEK inhibitor, PD98059 (50 μm, starting 20 min before TBS, black line) on TBS-LTP (G) and HFS-LTP (H) in WT mice. I, J, Effect of the adenosine A2 receptor blocker, SCH58261 (50 nm) (starting 20 min before TBS, black line) on TBS-LTP (I) and HFS-LTP (J). K, Effect of FSK, TBS, and HFS on PKA activation/phosphorylation. Top, Representative Western blot. Bottom, Quantitative analysis of Western blots. Data are means ± SEM for 3 slices from 3 animals in each group. *p < 0.05, compared with LFS control (one-way ANOVA followed by Bonferroni test). PD98059 or SCH58261 was applied 30 min before stimulation. Guoqi Zhu et al. J. Neurosci. 2015;35:621-633 ©2015 by Society for Neuroscience