Volume 55, Issue 4, Pages (April 1999)

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Volume 55, Issue 4, Pages 1277-1283 (April 1999) Angiotensin II inhibits interleukin-1β–induced nitric oxide production in cultured rat mesangial cells Minoru Kihara, Machiko Yabana, Yoshiyuki Toya, Shunichi Kobayashi, Takayuki Fujita, Tamio Iwamoto, Tomoaki Ishigami, Satoshi Umemura Kidney International Volume 55, Issue 4, Pages 1277-1283 (April 1999) DOI: 10.1046/j.1523-1755.1999.00377.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Dose-dependent increase in nitrite accumulation (A) and nitric oxide synthase (NOS)-II mRNA expression (B) stimulated by interleukin (IL)-1β in cultured rat mesangial cells. Values are expressed as means ± sem from four experiments. *P < 0.01 vs. nonstimulated control. Kidney International 1999 55, 1277-1283DOI: (10.1046/j.1523-1755.1999.00377.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Effect of angiotensin II on interleukin (IL)-1β–stimulated nitric oxide (NO) formation (A) and nitric oxide synthase (NOS)-II mRNA levels (B). Glomerular mesangial cells were stimulated with 100 U/ml IL-1β in the presence of test medium or its vehicle. Values are expressed as means ± sem from six to eight experiments. *P < 0.01 vs. vehicle-treated control. Kidney International 1999 55, 1277-1283DOI: (10.1046/j.1523-1755.1999.00377.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Effect of transforming growth factor-β (TGF-β) and TGF-β–neutralizing antibody (α-TGF-β, anti–TGF-β antibody) experiments on interleukin (IL)-1β–stimulated nitric oxide (NO) formation (A) and NOS-II mRNA levels (B). Mesangial cells were stimulated with 100 U/ml IL-1β in the presence of the test medium or its vehicle. Values are expressed as means ± sem from four experiments. *P < 0.01 vs. vehicle-treated control. Kidney International 1999 55, 1277-1283DOI: (10.1046/j.1523-1755.1999.00377.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Effect of anti-TGF-β antibody (α-TGF-β) on angiotensin II-mediated inhibition of interleukin (IL)-1β-stimulated nitric oxide (NO) formation. Mesangial cells were stimulated with 100 U/ml IL-1β in the presence of test medium or its vehicle. Values are expressed as means ± sem from four experiments. *P < 0.01 vs. vehicle-treated control. Kidney International 1999 55, 1277-1283DOI: (10.1046/j.1523-1755.1999.00377.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 5 Effect of vehicle (•), angiotensin II (▪) and transforming growth factor-β (TGF-β; ▴) on the stability of nitric oxide synthase (NOS)-II mRNA. After the stimulation of 100 U/ml interleukin (IL)-1β for 24hours, mesangial cells were treated with vehicle, 10-6 m angiotensin II, or 5 μg/ml TGF-β in the presence of 5 μg/ml actinomycin D. The radioactivity of NOS-II mRNA was divided by that of 18S rRNA. The normalized radioactivity was plotted as a percentage of 0-hour control against time. The data are expressed as means of three experiments. Kidney International 1999 55, 1277-1283DOI: (10.1046/j.1523-1755.1999.00377.x) Copyright © 1999 International Society of Nephrology Terms and Conditions