Volume 82, Issue 11, Pages (December 2012)

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Volume 82, Issue 11, Pages 1223-1230 (December 2012) Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized patients with euvolemic hyponatremia William T. Abraham, Johannes Hensen, Peter A. Gross, Daniel G. Bichet, Richard C. Josiassen, DeoDatta S. Chafekar, Cesare Orlandi Kidney International Volume 82, Issue 11, Pages 1223-1230 (December 2012) DOI: 10.1038/ki.2012.275 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Subject disposition. *In the placebo group, two subjects died during the treatment period and two subjects died during the 30-day follow-up period. Kidney International 2012 82, 1223-1230DOI: (10.1038/ki.2012.275) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 Symptoms of hyponatremia in total randomized intent-to-treat (ITT) population at baseline. Kidney International 2012 82, 1223-1230DOI: (10.1038/ki.2012.275) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 3 Mean central serum sodium concentration over time (intent-to-treat population (ITT), observed value). Error bars represent s.e. EOT, end of treatment (overall summary value of all end-of-treatment values, regardless of when actual end of treatment occurred); f/u 7, follow-up on day 7. *P<0.05 vs. placebo for mean change from baseline. Kidney International 2012 82, 1223-1230DOI: (10.1038/ki.2012.275) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 4 Normalized daily average area under the curve (AUC) of serum sodium concentration (days 0–3 and days 0–30). *P<0.05 by ANCOVA. ANCOVA, analysis of covariance; LSM, least-squared mean. Kidney International 2012 82, 1223-1230DOI: (10.1038/ki.2012.275) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 5 Time to normalization of serum sodium concentration. Kidney International 2012 82, 1223-1230DOI: (10.1038/ki.2012.275) Copyright © 2012 International Society of Nephrology Terms and Conditions