M.B. Stokes, B. Aronoff, D. Siegel, V.D. D'Agati Kidney International

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Dysproteinemia-related nephropathy associated with crystal-storing histiocytosis M.B. Stokes, B. Aronoff, D. Siegel, V.D. D'Agati Kidney International Volume 70, Issue 3, Pages 597-602 (August 2006) DOI: 10.1038/sj.ki.5001524 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Fractured, eosinophilic cast (myeloma cast) surrounded by mononuclear cells (arrow) (hematoxylin and eosin stain; original magnification × 600). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 Tubular epithelium displays eosinophilic needle-shaped intracytoplasmic crystalline inclusions (arrow) (hematoxylin and eosin stain; original magnification × 1000). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 3 Numerous interstitial cells display eosinophilic needle-shaped intracytoplasmic crystalline inclusions (hematoxylin and eosin stain; original magnification × 1000). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 4 Interstitial cells stain for CD68 confirming histiocytic phenotype. Some of these cells display intracytoplasmic crystals (arrow) (immunoperoxidase stain, original magnification × 600). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 5 Electron microscopy demonstrates rod-shaped and rhomboid-shaped intracytoplasmic crystalline inclusions within tubular epithelium (electron micrograph; original magnification × 4000). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 6 Tubular epithelium contains intracytoplasmic rhomboid-shaped electron-dense crystalline structures, focally accompanied by a unit membrane (arrow) (electron micrograph; original magnification × 12 000). Kidney International 2006 70, 597-602DOI: (10.1038/sj.ki.5001524) Copyright © 2006 International Society of Nephrology Terms and Conditions