Referred visceral hyperalgesia in wild-type (+/+) and Nav1

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Referred visceral hyperalgesia in wild-type (+/+) and Nav1 Referred visceral hyperalgesia in wild-type (+/+) and Nav1.8-null (−/−) mice. Referred visceral hyperalgesia in wild-type (+/+) and Nav1.8-null (−/−) mice. Referred visceral hyperalgesia was measured as responses to mechanical stimulation of the hindpaws with von Frey hairs of five intensities in wild-type and Nav1.8-null mice. Data are shown as mean percentage response frequency ± SEM before (baseline) and 20 min after intracolonic instillation of 0.1% capsaicin (A), 20 min after intracolonic instillation of 1% mustard oil (B), and 4 hr after 300 mg/kg intraperitoneal cyclophosphamide (C). ∗p < 0.05, indicates forces where a significant difference between +/+ and −/− mice was observed. ANOVA revealed a significant difference overall between genotypes 20 min after intracolonic capsaicin (p = 0.03) and mustard oil (p = 0.02) but not after cyclophosphamide. Jennifer M. A. Laird et al. J. Neurosci. 2002;22:8352-8356 ©2002 by Society for Neuroscience