Fig. 6 Reduced mitochondrial respiration upon Lkb1 loss does not affect glial differentiation. Reduced mitochondrial respiration upon Lkb1 loss does not.

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Fig. 6 Reduced mitochondrial respiration upon Lkb1 loss does not affect glial differentiation. Reduced mitochondrial respiration upon Lkb1 loss does not affect glial differentiation. (A) Confocal analyses of MitoTracker staining on isolated myelinated nerve fibers of WT or Lkb1-deficient mice (cKO). (B) Representative electron microscopy images of mitochondria from control (siCont.) and Lkb1 knockdown (siLkb1) glial JoMa1.3 cells showing increased cristae width in the absence of Lkb1. Quantification was performed on 429 and 336 cristae from mitochondria of control and Lkb1-silenced cells, respectively. (C) Mitochondrial mass was quantified by fluorescence-activated cell sorting analyses with MitoTracker Green staining (n = 3). (D) Mitochondrial topology of glial JoMa1.3 cells stained with MitoTracker Red was analyzed by confocal microscopy (n = 3). (E) Representative trace showing change in oxygen consumption rates (OCRs) during a mitochondrial stress assessed by Seahorse analyses on control (siCont.) and Lkb1-silenced (siLkb1) glial JoMa1.3 cells. Right: Quantification (n = 12). (F) Representative curves showing change in oxygen consumption (OCR, left) upon chloroalanine treatment. Right: Quantification of % OCR relative to control cells (siCont. with the control condition of treatment) (n = 4). Ant.A, antimycin A; FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone; Rot, rotenone. Anca G. Radu et al. Sci Adv 2019;5:eaau5106 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).