Fig. 2 Activation of LRRK2 kinase in nigrostriatal dopamine neurons in human iPD postmortem brain tissue. Activation of LRRK2 kinase in nigrostriatal dopamine.

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Fig. 2 Activation of LRRK2 kinase in nigrostriatal dopamine neurons in human iPD postmortem brain tissue. Activation of LRRK2 kinase in nigrostriatal dopamine neurons in human iPD postmortem brain tissue. (A) Shown are the pSer1292 proximity ligation signal (red) and pThr73-Rab10 immunofluorescence signal (gray) in sections of substantia nigra from a healthy, age-matched control human brain (top row) and a brain from an individual with iPD (bottom row). In the control brain, there was little pSer1292 or pThr73-Rab10 signal, but in the iPD brain, there were strong signals for both. TH, tyrosine hydroxylase, a marker of dopamine neurons (blue). (B) Quantification of pSer1292 proximity ligation signal in eight control brains and seven iPD brains. Statistical comparison by unpaired two-tailed t test. (C) Quantification of pThr73-Rab10 signal in eight control brains and seven iPD brains. Statistical comparison by unpaired two-tailed t test. (D) Shown are 14-3-3–LRRK2 proximity ligation signal (red) and pThr73-Rab10 immunofluorescence signal (gray) in sections of substantia nigra from a control human brain (top row) and a brain from an individual with iPD (bottom row). In the control brain, there was a strong 14-3-3–LRRK2 proximity ligation signal and little pThr73-Rab10 signal, but in the iPD brain, the opposite pattern was seen. (E) Quantification of 14-3-3–LRRK2 proximity ligation signal in eight control brains and seven iPD brains. Statistical comparison by unpaired two-tailed t test. Roberto Di Maio et al., Sci Transl Med 2018;10:eaar5429 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works