Cardiac Resynchronization Therapy: Long-Term Alternative to Cardiac Transplantation? Bert Hansky, MD, Jürgen Vogt, MD, Armin Zittermann, PhD, Holger Güldner,

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Cardiac Resynchronization Therapy: Long-Term Alternative to Cardiac Transplantation? Bert Hansky, MD, Jürgen Vogt, MD, Armin Zittermann, PhD, Holger Güldner, MD, Johannes Heintze, MD, Uwe Schulz, MD, Dieter Horstkotte, MD, PhD, Gero Tenderich, MD, PhD, Reiner Körfer, MD, PhD The Annals of Thoracic Surgery Volume 87, Issue 2, Pages 432-438 (February 2009) DOI: 10.1016/j.athoracsur.2008.09.071 Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Kaplan–Meier estimates of freedom from therapy failure in cardiac transplant candidates with cardiac resynchronization therapy. Dotted lines indicate 95% confidence intervals. The Annals of Thoracic Surgery 2009 87, 432-438DOI: (10.1016/j.athoracsur.2008.09.071) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Time course of various outcome variables during the first 6 months of cardiac resynchronization therapy in cardiac transplant candidates who survived (N = 381) or did not survive (N = 111) during follow-up. The two-factor repeated-measures analysis of variance revealed significant time effects for New York Heart Association (NYHA) class (p < 0.001), maximal oxygen consumption (V̇o2max; p < 0.001), 6-minute hall-walk distance (p < 0.001), and left ventricular end-diastolic diameter (LVEDD; p < 0.001). Significant differences between groups were present for New York Heart Association class (p < 0.05), maximal oxygen consumption (p < 0.01), 6-minute hall-walk distance (p < 0.01), and left ventricular end-diastolic diameter (p < 0.001). *p < 0.05; **p < 0.01; ***p < 0.001 between patients with and without an event during follow-up. (BL = baseline.) The Annals of Thoracic Surgery 2009 87, 432-438DOI: (10.1016/j.athoracsur.2008.09.071) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Allocation scheme for cardiac resynchronization therapy (CRT) or cardiac transplantation (CTx). (VAD = ventricular assist device.) The Annals of Thoracic Surgery 2009 87, 432-438DOI: (10.1016/j.athoracsur.2008.09.071) Copyright © 2009 The Society of Thoracic Surgeons Terms and Conditions