CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours.

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CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. CBD elevates AEA levels in poly-(I:C)–stimulated HaCaT cells after 6 hours. Concentrations of AEA (A), 2-AG (B), PEA (C), and OEA (D) in poly-(I:C)–stimulated HaCaT cells (100 μg/ml, 6 hours, 37°C) in the presence of vehicle or CBD (20 μM). Data represent the mean ± S.E.M. of three independent experiments performed in triplicate. ***P < 0.001 vs. vehicle; °°°P < 0.001 vs. poly-(I:C) + vehicle. Stefania Petrosino et al. J Pharmacol Exp Ther 2018;365:652-663 Copyright © 2018 by The American Society for Pharmacology and Experimental Therapeutics