Figure 2. Relationship between six B7 family members and overall survival in breast cancer patients. (A) Using The Cancer Genome Atlas survival data and.

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Figure 2. Relationship between six B7 family members and overall survival in breast cancer patients. (A) Using The Cancer Genome Atlas survival data and Cutoff Finder (http://molpath.charite.de/cutoff/), we correlated the messenger RNA (mRNA) expression level of B7 family members with overall survival. Six B7 family members, CD274, CD276, HHLA2, ICOSLG, NCR3LG1, and PDCD1LG2, had prognostic value in patients with breast cancer (log-rank p<0.05). Notably, high CD274, HHLA2, and PDCD1LG2 expression correlated with longer survival, whereas high CD276, ICOSLG, and NCR3LG1 expression correlated with shorter survival. (B) Real-time polymerase chain reaction was performed to determine CD274, CD276, HHLA2, ICOSLG, NCR3LG1, and PDCD1LG2 expression in MCF7, MDA-MB-231, SK-BR-3 and human fibrocystic disease epithelium cell lines MCF10A.CD274=cluster of differentiation 274; HHLA2=HERV-H LTR-associating 2; PDCD1LG2=programmed cell death 1 ligand 2; CD276=cluster of differentiation 276; ICOSLG=inducible T-cell costimulator ligand; NCR3LG1=natural killer cell cytotoxicity receptor 3 ligand 1. *p<0.05. Figure 2. Relationship between six B7 family members and overall survival in breast cancer patients. (A) Using The Cancer Genome Atlas survival data and Cutoff Finder (http://molpath.charite.de/cutoff/), we correlated the messenger RNA (mRNA) expression level of B7 family members… J Breast Cancer. 2018 Dec;21(4):371-381. https://doi.org/10.4048/jbc.2018.21.e60