Figure 1. Identification of differentially expressed messenger RNAs (mRNAs) in the The Cancer Genome Atlas (TCGA) BRCA database. (A) Heat map of the log2-fold.

Slides:



Advertisements
Similar presentations
Parallel human genome analysis: Microarray-based expression monitoring of 1000 genes Mark Schena, Dari Shalon, Renu Heller, Andrew Chai, Patrick O. Brown,
Advertisements

1 April, 2005 Chapter C4.1 and C5.1 DNA Microarrays and Cancer.
Methodology Control (no treatment) Estrogen (5 uM) 4-nonylphenol (5 uM) Cultured Cells, Isolated RNA, RTed to cDNA Data analyzed by Spotfire software RT-PCR.
Unit 3 Vocabulary Amelia N.. Algebraic Expression An expression that contains a variable. Examples: 10/p=2 p+11=20.
Methodology U937 Human Immune Cells Control (No treatment) (n=4) Estrogen (5 uM) (n=4) 4-nonylphenol (5 uM) (n=4) Cultured Cells, RNA Isolation, RT (to.
Date of download: 6/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association of BRCA1 and BRCA2 Mutations With Survival,
Date of download: 6/22/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Association of a Leukemic Stem Cell Gene Expression.
Figure 3. Profiles of chemokine network in adipose tissues between lean and obese postmenopausal women. (A) Expression levels of chemokine ligands and.
Vignesh Ramachandran SMART Summer Research Program
Volume 389, Issue 10087, Pages (June 2017)
From: Epigenetic instability of imprinted genes in human cancers
Gene expression.
KDM1B Expression in Richardson Breast 2
RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma  Julien Faget, PhD, Caroline Contat, MS, Nadine.
The cBio Cancer Genomics Portal.
Fig. 8. Recurrent copy number amplification of BRD4 gene was observed across common cancers. Recurrent copy number amplification of BRD4 gene was observed.
Strategy Description Discovery Validation Application
سرطان الثدي Breast Cancer
Nat. Rev. Urol. doi: /nrurol
Figure 3 Altered adaptive immune functions after sepsis
A B C Supplementary figure S7
B lymphocytes produce antibodies.
Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue  Louisa Cheung, Rachel M. Fisher, Natalia Kuzmina,
Plots derived from provisional TCGA data from sequencing and expression analyses of invasive breast carcinoma cases. Plots derived from provisional TCGA.
Potential role of circulating microRNAs as a biomarker for unexplained recurrent spontaneous abortion  Weibing Qin, M.D., Ph.D., Yunge Tang, M.D., Ning.
Altered microRNA expression in stenoses of native arteriovenous fistulas in hemodialysis patients  Lei Lv, MD, Weibin Huang, MD, Jiwei Zhang, MD, Yaxue.
Volume 2, Issue 4, Pages (April 2008)
HIS-24 regulates expression of infection-inducible genes.
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival  Ryan K. Van Laar 
Characterization of Fibroblast Growth Factor Receptor 1 in Small-Cell Lung Cancer  Anish Thomas, MD, Jih-Hsiang Lee, MD, Zied Abdullaev, PhD, Kang-Seo.
Genetic and Immune Profiles of Solid Predominant Lung Adenocarcinoma Reveal Potential Immunotherapeutic Strategies  Zhong-Yi Dong, PhD, Chao Zhang, MD,
Transcriptional Consequences of 16p11
(A) Schematic representation of the conditional Lats1 locus.
Cyclin E1 Is Amplified and Overexpressed in Osteosarcoma
Figure 3 Examples of gene expression heterogeneity
Volume 25, Issue 5, Pages e5 (October 2018)
Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients  Leila Aghili, Jasmine Foo, James.
Working with RNA-Seq Data
Volume 12, Issue 6, Pages (December 2003)
Cluster analysis and pathway-based characterization of differentially expressed genes and proteins from integrated proteomics. Cluster analysis and pathway-based.
Fold Change of hsa-miR-3687 (T/N)(log2)
Cutaneous Anaplastic Large Cell Lymphoma and Peripheral T-Cell Lymphoma NOS Show Distinct Chromosomal Alterations and Differential Expression of Chemokine.
Limited transcriptomic changes upon HOTAIR RNA overexpression in MDA‐MB‐231 breast cancer cells Limited transcriptomic changes upon HOTAIR RNA overexpression.
Genomic Profiling of Human Leishmania braziliensis Lesions Identifies Transcriptional Modules Associated with Cutaneous Immunopathology  Fernanda O. Novais,
Patterns of Somatically Acquired Amplifications and Deletions in Apparently Normal Tissues of Ovarian Cancer Patients  Leila Aghili, Jasmine Foo, James.
Statistical chart of significantly differentially expressed genes
Single-cell atlas of lincRNA expression during mESC to NPC differentiation. Single-cell atlas of lincRNA expression during mESC to NPC differentiation.
NRG1 rearrangements are found in multiple solid tumors.
Figure 2. Relationship between six B7 family members and overall survival in breast cancer patients. (A) Using The Cancer Genome Atlas survival data and.
Figure 1. Chloride channel-3 (CIC-3) expression in breast tumor tissues. (A) Chloride channels (ClC-1–7, CFTR) are expressed in human breast cancer tissues.
Figure 4. MicroRNA (miR)-195 and miR-497 directly targets CD274
GSTZ1‐1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone AGSTZ1 mRNA expression in HCC and paired non‐tumor.
A, unsupervised hierarchical clustering of the expression of probe sets differentially expressed in the oral mucosa of smokers versus never smokers. A,
Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.
Treatmentalgorithm for metastatic TNBC patients consideringthe incorporation of PARPis and immunotherapy. *Defined as PD-L1 expression on tumour-infiltratingimmune.
Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.
CREBBP loss-of-function results in gene expression repression signature. CREBBP loss-of-function results in gene expression repression signature. A–D,
PD-L1 is expressed in breast cancer.
BCL-2 and BCL-XL expression alters with maturation stage of the T cell
Gene expression patterns of SLC and ABC transporters in normal and tumor tissues. Gene expression patterns of SLC and ABC transporters in normal and tumor.
Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.
Mutational signature analysis of WES data from patients with advanced PDAC. A, Projection of signatures representing four main mutational processes identified.
Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.
Expression of TGFβ ligands in GBM
The ovarian cancer cell lines modestly recapitulate the spectrum of mutations found in primary ovarian tumors. The ovarian cancer cell lines modestly recapitulate.
CASP8 mutations are associated with fewer CNAs and RAS family mutations. CASP8 mutations are associated with fewer CNAs and RAS family mutations. A, number.
Integrated analysis of gene expression and copy number alterations.
Highly metastatic PDAC cells have a unique gene signature, which is not preserved in metastases but predicts poor patient outcome. Highly metastatic PDAC.
Fig. 1. FAM83H over-expression is associated with poor prognosis of CC
Characteristic gene expression patterns distinguish LCH cells from other immune cells present in LCH lesions. Characteristic gene expression patterns distinguish.
Presentation transcript:

Figure 1. Identification of differentially expressed messenger RNAs (mRNAs) in the The Cancer Genome Atlas (TCGA) BRCA database. (A) Heat map of the log2-fold expression changes in 10 B7 family members mRNAs in the TCGA BRCA database (n=1,092). The horizontal row represents different mRNAs, and the vertical column represents different patients. Green squares indicate increases, and red squares indicate decreases. (B) Statistical analysis of altered expression of B7 family members in the TCGA BRCA data. The false discovery rate for all data is less than 0.01.CD80=cluster of differentiation 80; CD86=cluster of differentiation 86; CD274=cluster of differentiation 274; ICOSLG=inducible T-cell costimulator ligand; CD276=cluster of differentiation 276; VTCN1=V-set domain containing T cell activation inhibitor 1; C10orf54=chromosome 10 open reading frame 54; NCR3LG1=natural killer cell cytotoxicity receptor 3 ligand 1; HHLA2=HERV-H LTR-associating 2; PDCD1LG2=programmed cell death 1 ligand 2. *p<0.05. Figure 1. Identification of differentially expressed messenger RNAs (mRNAs) in the The Cancer Genome Atlas (TCGA) BRCA database. (A) Heat map of the log2-fold expression changes in 10 B7 family members mRNAs in the TCGA BRCA database (n=1,092). The horizontal row… J Breast Cancer. 2018 Dec;21(4):371-381. https://doi.org/10.4048/jbc.2018.21.e60