PHARM 122.3 Library Orientation Presented by: Vicky Duncan September 17, 2018

Outline Evaluating information What about Wikipedia? How to find medicinal chemistry resources Finding information about the chemistry and physical chemistry of drugs Finding current literature on a drug Citing references Outline

CRAAP Test This video provides a nice overview of using CRAAP to evaluate sources of information… It applies to both online and print sources, websites and peer-reviewed articles

CRAAP This Photo by Unknown Author is licensed under CC BY-SA-NC

What about Wikipedia? It is an “open” database Quality varies article to article WikiProject Medicine is an effort made by a group of volunteer health professionals to keep key medical topics in Wikipedia up to date WikiProject Medicine has been taken on by groups of medical students etc. Have published an extensive guide on identifying quality resources, and making entries available in languages other than English

Finding Medicinal Chemistry Resources It’s a good idea to do some reading “around” your topic before you start your assignment You will find books (print and online) in the library catalogue under the subject heading “Pharmaceutical Chemistry” You can also browse the books at the call number RS 403 Finding Medicinal Chemistry Resources

Finding information about the chemistry and physical chemistry of drugs You can find this information in a number of places, including the Merck Index, and (Wikipedia) Best Bets… Merck Index Health Canada Drug Product database PubChem

Finding Current Literature on a Drug You have a few choices available: PubMed / Medline Scopus Embase International Pharmaceutical Abstracts Google Scholar

What is Medline? A database which indexes over 5600 peer-reviewed journals in the biomedical sciences Contains over 26 million citations to journal articles Does not include theses, technical reports, pre- prints, books, or patents

How is it different than PubMed? Designed for the layperson Freely available Contains additional life sciences journals Contains in-process citations, and “Ahead of Print” citations Medline (OVID) Subscription based Guides you through the searching process User friendly interface which is the same for all OVID databases (PsycINFO, Embase, ERIC, etc.)

What do PubMed and Medline search? The full record of each journal article in the database But not the fulltext of the article Search UI: 19064532. What is meant by “the full record”? I’ll demonstrate by showing you one… Show the full record, then start the demo search by looking for information on “Acetaminophen” Explain mapping to subject heading / subheadings / focus – mention subheadings that will be useful to them

Subheadings Used to narrow down your search to a particular aspect(s) of your topic Be cautious about applying them the first time you run through your search. Often you won’t need to go back and apply them because your combination of MeSH terms identifies a nice number of relevant articles…but if you are overwhelmed by irrelevant results, try applying relevant subheadings

Boolean Operators AND, OR, NOT Used to join together different concepts in a research question It’s really important to use them properly

Focus Allows you to retrieve only the articles which have the MeSH heading selected as one of the foci of the article Useful when you are retrieving too much information, and its not all relevant - Because this is a large database, you will most likely retrieve many articles. To try to identify the more relevant ones, try using the “Focus” feature with the MeSH heading –

Limits Age Gender Geography Study type Date of publication Language Check tags Core clinical journals another strategy is to limit to the Publication type “review”

What is Google Scholar? Google Scholar includes journal and conference papers, theses and dissertations, academic books, pre-prints, abstracts, technical reports and other scholarly literature from all broad areas of research. You'll find works from a wide variety of academic publishers, professional societies and university repositories, as well as scholarly articles available anywhere across the web. Google Scholar also includes court opinions and patents Ahem, we index papers, not journals.  From: https://scholar.google.ca/intl/en/scholar/help.html#coverage But does not provide a list of the journals that are scanned, neither does it “index” the whole journal…just selected articles…and we don’t know how they are selecting those articles

What does it search? The journal citation (author/title/source/abstract) The fulltext of the article Searches the citation of the article, as well as the fulltext of the article

Features Related articles Maps to full text at U of S Can be imported using a citation reference manager Demonstrate using Google Scholar through the library website, and show a sample search where we can see the Related Articles. Go into “settings” to show how to set up linking to fulltext at U of S, and importing to the citation manager of your choice

Citing References Your assignment asks you to submit references in the style of the journal Pharmaceutical Research, which follows Vancouver Style Use a citation manager such as Mendeley or Zotero, or follow the examples in the website above Word 2016 does not include Vancouver style as an option

Questions? Feel free to contact me for any library or research question! Phone: 966-6023 Vicky.Duncan@usask.ca