Helium-induced late preconditioning in the rat heart in vivo†

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Helium-induced late preconditioning in the rat heart in vivo† R. Huhn, A. Heinen, N.C. Weber, S. Hieber, M.W. Hollmann, W. Schlack, B. Preckel British Journal of Anaesthesia Volume 102, Issue 5, Pages 614-619 (May 2009) DOI: 10.1093/bja/aep042 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a) Histogram showing the experimental protocol from part 1. Con, control; He, helium; LPC, late preconditioning; NS-398, selective COX-2 inhibitor (5 mg kg−1 i.p.) administered 30 min before preconditioning. Spontaneously breathing rats received helium or oxygen 24 h before ischaemia/reperfusion. (b) Histogram showing the experimental protocol from part 2. All rats were treated on three subsequent days, either with 30% helium or with 30% oxygen, interspersed by 24 h between each treatment before ischaemia/reperfusion. British Journal of Anaesthesia 2009 102, 614-619DOI: (10.1093/bja/aep042) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions