Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery M. Grossherr, A. Hengstenberg,

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Presentation transcript:

Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery M. Grossherr, A. Hengstenberg, T. Meier, L. Dibbelt, B.W. Igl, A. Ziegler, P. Schmucker, H. Gehring British Journal of Anaesthesia Volume 102, Issue 5, Pages 608-613 (May 2009) DOI: 10.1093/bja/aep053 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 Dosing and concentration profiles of propofol in patients with a low (3 mg kg−1 h−1, n=6) and a high (6 mg kg−1 h−1, n=6) dosage of propofol after induction of anaesthesia. The horizontal axis indicates the time points (T) studied: T0 before propofol and T1–T4 under continuous infusion of propofol (sampling 10, 20, 30, and 40 min after initiation of the infusion). After CPB, on the intensive care ward, propofol 3 mg kg−1 h−1 was infused until T5. Row 1: propofol concentration in expired gas (cPG); row 2: propofol concentration in plasma (cPPL); row 3: propofol dose. Differences in cPPL, between the groups, were measured at T2 ($P=0.006), T3 (§P=0.01), and T4 (*P=0.004). Differences between time points for Groups L and H are demonstrated for cPPL and cPG (#P=0.031). British Journal of Anaesthesia 2009 102, 608-613DOI: (10.1093/bja/aep053) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 Ratio of propofol concentrations in breath gas (cPG) and in plasma (cPPL) at time points T0 –T6 related to T4 (Tx/T4). Ratios of cPG and cPPL at each time point were compared for Group L (n=6; 3 mg kg−1 h−1) and Group H (n=6; 6 mg kg−1 h−1). Ratios differed between cPG and cPPL for Group L at T1 and T6 (*P=0.031), and for Group H at T1 and T2 (*P=0.031). British Journal of Anaesthesia 2009 102, 608-613DOI: (10.1093/bja/aep053) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions