Fig. 6 RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. RUNX/CBFB interaction inhibitor, Ro5-3335,

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Fig. 6 RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. RUNX/CBFB interaction inhibitor, Ro5-3335, significantly decreases mouse neurofibroma growth in vivo. (A) Waterfall plot showed mouse tumor volume change. Data from each mouse were shown as a single bar. Change in tumor volume was quantified between 7 and 9 months for each individual mouse treated with vehicle control (control) (black bars; n = 13) or Ro5-3335 (gray bars; n = 10) for 8 weeks. (B and C) Ro5-3335–inhibited neurofibroma cell proliferation readout by the percentage of Ki67+ cells. (D and E) Ro5-3335–induced neurofibroma cell apoptosis as assessed by the percentage of CC3+ cells. (F and G) Relative mRNA expression of Ro5-3335–treated mouse neurofibromas compared with vehicle controls on up- (F) and down-regulated (G) genes. (H) Western blot of PMP22 in Nf1fl/fl;DhhCre tumors (1 and 2) and Ro5-3335–treated Nf1fl/fl;DhhCre tumors (3 and 4). β-Actin was used as loading control. *P < 0.05 and **P < 0.01. Ashley Hall et al. Sci Adv 2019;5:eaau8389 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).