Fig. 8. SMC Col15a1 knockout resulted in a decrease in lesion cell death. A: representative immunofluorescent images of SMC YFP+/+ Col15a1wt/wt, Apoe−/−

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Fig. 8. SMC Col15a1 knockout resulted in a decrease in lesion cell death. A: representative immunofluorescent images of SMC YFP+/+ Col15a1wt/wt, Apoe−/− (n = 11) and SMC YFP+/+ Col15a1Δ/Δ, Apoe−/− (n = 13) lesions stained for the cell death marker cleaved caspase-3 (CASP3+). B and C: quantification of CASP3+ cells counted per lesion (B) and percentages of CASP3+ cells within lesions (C; CASP3+/DAPI+) showed that SMC YFP+/+ Col15a1Δ/Δ, Apoe−/− mice have significantly fewer dying cells compared with SMC YFP+/+ Col15a1wt/wt, Apoe−/− mice. Values represent means ± SE. Scale bars = 100 µm and on zoom in images 25 µm. ^P value from a Mann-Whitney U-test. DOI: (10.1152/ajpheart.00029.2017)