Chromatin Scanning by Dynamic Binding of Pioneer Factors

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

The Genetic Makeup of the Drosophila piRNA Pathway Dominik Handler, Katharina Meixner, Manfred Pizka, Kathrin Lauss, Christopher Schmied, Franz Sebastian.

SOD1 Integrates Signals from Oxygen and Glucose to Repress Respiration Amit R. Reddi, Valeria C. Culotta Cell Volume 152, Issue 1, Pages (January.

HnRNP L and HnRNP A1 Induce Extended U1 snRNA Interactions with an Exon to Repress Spliceosome Assembly Ni-Ting Chiou, Ganesh Shankarling, Kristen W. Lynch.

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

An Ancient Mechanism for Splicing Control: U11 snRNP as an Activator of Alternative Splicing Jens Verbeeren, Elina H. Niemelä, Janne J. Turunen, Cindy.

Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart Moshi Song, Gerald W. Dorn Cell Metabolism Volume 21, Issue.

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth Irit Shachrai, Alon Zaslaver, Uri Alon, Erez Dekel Molecular.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Germline Energetics, Aging, and Female Infertility Jonathan L. Tilly, David A. Sinclair Cell Metabolism Volume 17, Issue 6, Pages (June 2013) DOI:

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

E3-Independent Monoubiquitination of Ubiquitin-Binding Proteins Daniela Hoeller, Christina-Maria Hecker, Sebastian Wagner, Vladimir Rogov, Volker Dötsch,

Volume 47, Issue 1, Pages (July 2012)

Cold Signal Shuttles from Membrane to Nucleus

Sonja Schmid, Thorsten Hugel Molecular Cell

Dun1 Counts on Rad53 to Be Turned On

ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome

PDF Has Found Its Receptor

Pancreatic β cells: Responding to the matrix

Volume 49, Issue 1, Pages 3-5 (January 2013)

RNase E Finds Some sRNAs Stimulating

The DNA Damage Response: Ten Years After

Kai Papenfort, Jörg Vogel Molecular Cell

Targeting HSP70 for Cancer Therapy

Engineering the End: DNA Processing at Human Telomeres

Saving the Ends for Last: The Role of Pol μ in DNA End Joining

Skill Development in Graduate Education

The Case of the Disappearing Drug Target

How To Choose a Good Scientific Problem

A New Window onto Translational Repression by Bacterial sRNAs

Volume 73, Issue 1, Pages 1-3 (January 2012)

Jan Philipp Junker, Alexander van Oudenaarden Molecular Cell

Volume 46, Issue 5, Pages (June 2012)

Chromatin Proteins Do Double Duty

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

William G. Kaelin, Peter J. Ratcliffe Molecular Cell

Eukaryotic Transcription Activation: Right on Target

Joseph W. Briggs, Jonathan D. Dinman Molecular Cell

Lucas T. Gray, Alan M. Weiner Molecular Cell

Stephen P. Muench, Martin van der Laan Molecular Cell

An Argonaute Protein Directs Nuclear Xrn2 Function

Volume 175, Issue 1, Pages 6-9 (September 2018)

Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War

Hijacking the DNA Damage Response to Enhance Viral Replication: γ-Herpesvirus 68 orf36 Phosphorylates Histone H2AX Anyong Xie, Ralph Scully Molecular.

MicroRNAs and Viral Infection

Volume 62, Issue 1, Pages (April 2016)

Volume 58, Issue 6, Pages (June 2015)

A Molecular Take on Aesop’s The Oak and the Reeds

Nuclear PI5P, Uhrf1, and the Road Not Taken

Breaching the Boundaries that Safeguard against Repression

Volume 49, Issue 1, Pages 1-3 (January 2013)

Destabilizing Heterochromatin: Does Swi6/HP1 Make the Choice?

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains Till Maurer, Ingrid E. Wertz Molecular Cell

The Cell Biology of Genomes: Bringing the Double Helix to Life

Volume 28, Issue 6, Pages (June 2008)

Apollo—Taking the Lead in Telomere Protection

The DNA Damage Response: Ten Years After

How To Choose a Good Scientific Problem

It Takes Two Binding Sites for Calcineurin and NFAT to Tango

Volume 61, Issue 2, Pages (January 2016)

S-Nitrosylation at the Interface of Autophagy and Disease

Volume 25, Issue 2, Pages (January 2007)

Volume 65, Issue 6, Pages (March 2017)

TFII-IΔ and TFII-Iβ: Unequal Brothers Fostering Cellular Proliferation

A New Window onto Translational Repression by Bacterial sRNAs

RNA Processing: Redrawing the Map of Charted Territory

Presentation transcript:

Chromatin Scanning by Dynamic Binding of Pioneer Factors Kenneth S. Zaret, Jonathan Lerner, Makiko Iwafuchi-Doi Molecular Cell Volume 62, Issue 5, Pages 665-667 (June 2016) DOI: 10.1016/j.molcel.2016.05.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Chromatin Scanning by Pioneer Factors Chromatin across the bottom of the figure is depicted as consisting of open domains, naive/unprogrammed domains, and repressed or heterochromatic domains. Pioneer factors (green blobs) are able to target the naive domains, whereas non-pioneer factors (gray blobs) are typically dependent upon pioneers for binding there (black arrow). The green arrows depict transient, on-and-off association with chromatin as the factors scan the different domains; the red bars indicate the factors being impeded from scanning certain domains. Molecular Cell 2016 62, 665-667DOI: (10.1016/j.molcel.2016.05.024) Copyright © 2016 Elsevier Inc. Terms and Conditions