Chromatin Scanning by Dynamic Binding of Pioneer Factors

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Chromatin Scanning by Dynamic Binding of Pioneer Factors Kenneth S. Zaret, Jonathan Lerner, Makiko Iwafuchi-Doi  Molecular Cell  Volume 62, Issue 5, Pages 665-667 (June 2016) DOI: 10.1016/j.molcel.2016.05.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Chromatin Scanning by Pioneer Factors Chromatin across the bottom of the figure is depicted as consisting of open domains, naive/unprogrammed domains, and repressed or heterochromatic domains. Pioneer factors (green blobs) are able to target the naive domains, whereas non-pioneer factors (gray blobs) are typically dependent upon pioneers for binding there (black arrow). The green arrows depict transient, on-and-off association with chromatin as the factors scan the different domains; the red bars indicate the factors being impeded from scanning certain domains. Molecular Cell 2016 62, 665-667DOI: (10.1016/j.molcel.2016.05.024) Copyright © 2016 Elsevier Inc. Terms and Conditions