Motoneuron numbers (mean ± SEM) in 48 hr control cultures (open bar) and in cultures treated with either 100 nm thrombin (hatched bars), 1 μm YVAD-CHO,

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Motoneuron numbers (mean ± SEM) in 48 hr control cultures (open bar) and in cultures treated with either 100 nm thrombin (hatched bars), 1 μm YVAD-CHO, or 10 μm DEVD-CHO (cross-hatched bars) or cotreated with thrombin and either caspase inhibitor (black bar... Motoneuron numbers (mean ± SEM) in 48 hr control cultures (open bar) and in cultures treated with either 100 nm thrombin (hatched bars), 1 μm YVAD-CHO, or 10 μm DEVD-CHO (cross-hatched bars) or cotreated with thrombin and either caspase inhibitor (black bars). Agents were added 2 hr after plating, and cells were counted 48 hr after the initial plating. Control cultures were grown in L-15 media. Treatment with 100 nm thrombin significantly decreased cell survival (**p < 0.01 vs control), whereas treatment with either YVAD-CHO or DEVD-CHO alone increased motoneuron survival by 180% (***p < 0.001 vs control). However, the decrease in motoneuron survival after 100 nm thrombin treatment was completely prevented by cotreatment with either YVAD-CHO or DEVD-CHO (#p < 0.001 vs 100 nmthrombin treatment); n = 3 experiments performed in triplicate. Victoria L. Turgeon et al. J. Neurosci. 1998;18:6882-6891 ©1998 by Society for Neuroscience