NestinCre-mediated deletion of CTCF results in activation of caspase-mediated apoptosis. NestinCre-mediated deletion of CTCF results in activation of caspase-mediated.

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NestinCre-mediated deletion of CTCF results in activation of caspase-mediated apoptosis. NestinCre-mediated deletion of CTCF results in activation of caspase-mediated apoptosis. A, Table of genotype ratios obtained during the embryonic period. Ratios at each time point were analyzed by a χ2 test. B, Immunodetection of CTCF in E12.5 control and CtcfNes-cre coronal forebrain sections. C, Immunodetection of CTCF in E14 control and CtcfNes-cre coronal forebrain sections. D, Quantification of AC3 immunostaining in E12.5, E14, and E15.5 forebrain tissue (n = 3). AC3+ cells were counted and expressed per unit area (square millimeter). E, Immunodetection of AC3 in E15.5 control and CtcfNes-cre basal ganglia. F, Immunodetection of AC3 in control and CtcfNes-cre at 4 DIV. Het, Ctcfflox/WT;Nestin-cre; Ctx, cortex; BG, basal ganglia; H, hippocampal hem. Error bars represent the SEM. Original magnification: B, C, 50×; D, 100×; E, 200×. Scale bars: B, 220 μm; C, 300 μm; E, 100 μm; F, 25 μm. L. Ashley Watson et al. J. Neurosci. 2014;34:2860-2870 ©2014 by Society for Neuroscience