Melagatran for thromboprophylaxis after mechanical valve implantation: Results in a heterotopic porcine model Jess L. Thompson, MD, Chad E. Hamner, MD,

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Presentation transcript:

Melagatran for thromboprophylaxis after mechanical valve implantation: Results in a heterotopic porcine model Jess L. Thompson, MD, Chad E. Hamner, MD, D. Dean Potter, MD, Matthew Lewin, MD, Thoralf M. Sundt, MD, Hartzell V. Schaff, MD The Journal of Thoracic and Cardiovascular Surgery Volume 134, Issue 2, Pages 359-365 (August 2007) DOI: 10.1016/j.jtcvs.2007.01.093 Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Cartoon depicting the heterotopic model. A valved graft has been implanted onto the aorta, with diversion of the bloodstream through the conduit by ligation of the aorta. (Used with permission of Mayo Foundation for Medical Education and Research.) The Journal of Thoracic and Cardiovascular Surgery 2007 134, 359-365DOI: (10.1016/j.jtcvs.2007.01.093) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Photographs illustrating thrombus accumulation on the explanted valves 30 days after implantation in animals receiving melagatran (A), dalteparin (B), or no anticoagulation therapy (C). Visual inspection shows that both melagatran and dalteparin decrease thrombus formation. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 359-365DOI: (10.1016/j.jtcvs.2007.01.093) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Photographs illustrating thrombus accumulation on the explanted valves 30 days after implantation in animals receiving melagatran (A), dalteparin (B), or no anticoagulation therapy (C). Visual inspection shows that both melagatran and dalteparin decrease thrombus formation. The Journal of Thoracic and Cardiovascular Surgery 2007 134, 359-365DOI: (10.1016/j.jtcvs.2007.01.093) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Box plots showing median (interquartile range) thrombus weight for the melagatran, dalteparin, and control groups. (Melagatran vs dalteparin and control, P = .04.) The Journal of Thoracic and Cardiovascular Surgery 2007 134, 359-365DOI: (10.1016/j.jtcvs.2007.01.093) Copyright © 2007 The American Association for Thoracic Surgery Terms and Conditions