SORCS1 and SORCS3 control energy balance and orexigenic peptide production Representative hematoxylin and eosin (H&E)‐stained sections of perigonadal white.

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SORCS1 and SORCS3 control energy balance and orexigenic peptide production Representative hematoxylin and eosin (H&E)‐stained sections of perigonadal white adipose tissue (WAT) and quadriceps muscle from 14‐ to 15‐week‐old WT and S1/3 KO mice. Scale bars: 100 μm. Adipocyte size distribution shows a decrease in the number of small cells and an increase in the number of large cells (% of total cell numbers) in perigonadal adipose tissue of S1/3 KO mice as compared to controls. For each mouse, 332–551 adipocytes across the tissue depot were analyzed on H&E‐stained sections (n = 4–5 mice/group). Two‐way ANOVA; P = 0.0207 for interaction between genotype and adipocyte size. Body composition as determined by NMR imaging in 6‐week‐old mice of the indicated genotypes. S1/3 KO mice show an increase in fat mass and a concomitant decrease in lean (fat‐free) mass as compared to WT controls (n = 5–6 animals/group). Representative H&E‐stained sections of perigonadal white adipose tissue (WAT) and quadriceps muscle from 6‐week‐old WT and S1/3 KO mice. Scale bars: 100 μm. n = 3–5 mice/genotype. Data information: Data in (B and C) are shown as mean ± SEM and were analyzed using two‐way ANOVA with Bonferroni post‐test (B) or two‐tailed unpaired t‐test (C). **P < 0.01. IF THIS IMAGE HAS BEEN PROVIDED BY OR IS OWNED BY A THIRD PARTY, AS INDICATED IN THE CAPTION LINE, THEN FURTHER PERMISSION MAY BE NEEDED BEFORE ANY FURTHER USE. PLEASE CONTACT WILEY'S PERMISSIONS DEPARTMENT ON PERMISSIONS@WILEY.COM OR USE THE RIGHTSLINK SERVICE BY CLICKING ON THE 'REQUEST PERMISSIONS' LINK ACCOMPANYING THIS ARTICLE. WILEY OR AUTHOR OWNED IMAGES MAY BE USED FOR NON-COMMERCIAL PURPOSES, SUBJECT TO PROPER CITATION OF THE ARTICLE, AUTHOR, AND PUBLISHER. EMBO Rep, Volume: 19, Issue: 4, First published: 12 February 2018, DOI: (10.15252/embr.201744810)