Peripheral terminals of Trpm8GFP axons are found in functionally distinct regions in the tooth. a, Schematic diagram of mouse molars indicating the termination.

Slides:



Advertisements
Similar presentations
Prednisone decreases podocyte apoptosis in experimental FSGS
Advertisements

Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman 
Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro
Effect of α2δ-1 ablation on distribution of CaV2
Extension of the GlyRβ binding site on gephyrin.
TIE2hi/VEGFAhi TEMs are present in the TMEM
Somatosensory Substrates of Flight Control in Bats
Nat. Rev. Cardiol. doi: /nrcardio
Clone patterns and frequencies produced by lines 168 and 688A.
Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.
Volume 13, Issue 10, Pages (December 2015)
Distinct Protein Domains and Expression Patterns Confer Divergent Axon Guidance Functions for Drosophila Robo Receptors  Bettina Spitzweck, Marko Brankatschk,
Topographically Distinct Epidermal Nociceptive Circuits Revealed by Axonal Tracers Targeted to Mrgprd  Mark J. Zylka, Frank L. Rice, David J. Anderson 
Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice
Figure 4 Representative images of skin biopsy sample
Single-Cell Transcript Analysis of Pancreas Development
Abdul Q. Sheikh, Janet K. Lighthouse, Daniel M. Greif  Cell Reports 
CD169+ macrophages mediate Lm translocation to the splenic T cell zones. CD169+ macrophages mediate Lm translocation to the splenic T cell zones. (A) Confocal.
Graded MAPK activation in the ventral ectoderm is instructive to establish a sharp border of Yan degradation. Graded MAPK activation in the ventral ectoderm.
TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.
A, Low-magnification (4×) Nissl-stained photomicrograph of the brain tissue section containing the medial ventral striatum depicted in A', outlined by.
Distinct collagen structures in the upper and lower neonatal dermis (related to Fig 1)‏ Distinct collagen structures in the upper and lower neonatal dermis.
Assessment of proliferation status of PDGFRα+ cells in developing mouse lungs Assessment of proliferation status of PDGFRα+ cells in developing mouse lungs.
Aljoscha Nern, Yan Zhu, S. Lawrence Zipursky  Neuron 
Single type II fibers visualized by intracellular labeling.
Upper cortical layer-enriched neuronal expression of HA-UPRT.
ILK knockdown decreases mTOR signaling in PKD kidneys.
Volume 10, Issue 8, Pages (March 2015)
V-SVZ cultures express transcription factors expected for region of origin. V-SVZ cultures express transcription factors expected for region of origin.
Cross-species comparisons.
GFP+ cells derived from a passaged neurosphere implant contribute to peripheral nerves and DRG. (A) After the removal of an ∼1-mm section of spinal cord,
Fig. 1. Overview of the nervous system of the adult S. roscoffensis.
Ectopic sprouting and proliferation in Rbpj veins.
Fig. 1. γ-Tubulin localizes in close proximity to centriole walls in interphase but within an extended PCM meshwork in mitosis.U2OS cells were fixed and.
Fig. 7. Representative images of control (Cas9+GFP) and Cas9+gRNA+GFP co-injected embryos on day 4 of culture, showing nuclear-imported GFP (green) and.
MET/β-catenin complexes during synapse development.
Remodelling of adult dermis originates from a population of fibroblasts in the hair follicle junctional zone. Remodelling of adult dermis originates from.
Protein expression of EAAT2 paralogs.
Dermal cells from human neonatal foreskin can be distinguished into fibroblasts and pericytes based on differential VLA-1 expression. Dermal cells from.
Overexpression of Lef-1 partially rescues tooth arrest in Sox2cKO embryos. Overexpression of Lef-1 partially rescues tooth arrest in Sox2cKO embryos. (A,B)
Schematic design of the SSM
Sox2 regulates dental epithelial stem cell proliferation and differentiation. Sox2 regulates dental epithelial stem cell proliferation and differentiation.
Abnormal adherens junctions between hub cells and GSCs in Lar mutants.
EEG-based classification accuracy for across- and within-expression discrimination of facial identity with temporally cumulative data (50–650 ms after.
Global cell proliferation replenishes epidermal cells.
Morphology of the four L1 IN populations.
RA signaling in early postnatal PFC
A schematic diagram illustrating the arrival of axons onto layer III neurons during normal development (top). A schematic diagram illustrating the arrival.
c-Fos in RFMes GABAergic neurons across groups.
Macaque Satb2-RGCs are synaptically connected to geniculate neurons.
IHC detection of p-mTOR Ser 2448 in subcortical white matter during postnatal rat CNS development. IHC detection of p-mTOR Ser 2448 in subcortical white.
Domain 3, comprising the basolateral calyx and the stretch of axon leading to the heminode, selectively expressed NaV channels, KCNQ3, and certain scaffolding.
Summary data for target shift experiments and transient recall of old memories observed in the second target shift task. Summary data for target shift.
Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. A–G,
Muscle microprocesses and contacts between myotubes and axons in E15 intercostal muscle. Muscle microprocesses and contacts between myotubes and axons.
Central Trpm8GFP axons terminate in superficial lamina of the spinal cord dorsal horn. a, GFP fluorescence reveals central axons of Trpm8GFP neurons in.
Proprioceptive sensory neurons and muscle spindles are marked reduced in adult Swl/+ mice. Proprioceptive sensory neurons and muscle spindles are marked.
GABAARs in RFMes GABAergic neurons across groups.
Expression of the snail c-Fos homolog.
An ipRGC axon collateral colocalized with the presynaptic marker bassoon makes contact with TH-positive DAC processes. An ipRGC axon collateral colocalized.
Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber organization and neuronal migration. Effects the genotypes of Rapgef2 and Rapgef6 on RG fiber.
Global levels of AcH4 are increased in DRG neurons after peripheral axotomy. Global levels of AcH4 are increased in DRG neurons after peripheral axotomy.
Abnormal morphologies are prevented by overexpression of CaN inhibitory peptide AKAP79 in APP/PS1 mouse brain. Abnormal morphologies are prevented by overexpression.
Dynamics of CREB hot spots in the nuclei of living cortical neurons.
Fig. 2 Large-area and high-density assembly of AuNPs.
Immunolocalization of TRPC3 in cerebellar paraffin sections from wild-type and TRPC3−/− mice. Immunolocalization of TRPC3 in cerebellar paraffin sections.
Quantification of TUNEL staining and OS length among the rab11a constructs. Quantification of TUNEL staining and OS length among the rab11a constructs.
ET-1 effect on neuronal viability and blood flow.
PC loss in Nhe6-null mouse cerebellum, female and male.
Fig. 5 Reconstitution of the dormant state using fetal ovaries.
Presentation transcript:

Peripheral terminals of Trpm8GFP axons are found in functionally distinct regions in the tooth. a, Schematic diagram of mouse molars indicating the termination zones of cold-sensitive C- (red) and Aδ-fibers (green) localized in the pulp and dentin, respecti... Peripheral terminals of Trpm8GFP axons are found in functionally distinct regions in the tooth. a, Schematic diagram of mouse molars indicating the termination zones of cold-sensitive C- (red) and Aδ-fibers (green) localized in the pulp and dentin, respectively. Cell rich odontoblast layer that separates the pulp and dentin is shown in blue (blue box). During a cold stimulus, C- and Aδ-fibers fire with distinct rates of discharge, latencies, and adaptation, as depicted in green box [schematic and data modeled after that of Byers and Narhi (2002) and Jyvasjarvi et al. (1987), respectively]. b, In a longitudinal section of a decalcified molar, Trpm8GFP fibers (green) cross the odontoblast layer located at the pulp–dentin border (dashed line) and extend into the dentin (arrowheads). Cell nuclei were stained with DAPI (blue). c, d, Immunostaining of mouse molars reveals Trpm8GFP axons are morphologically and neurochemically distinct. c, Colabeling of Trpm8GFP (green) and CGRP (red) axons in mouse molars show that both fiber types have asymmetrically distributed terminals that reside in the pulp (arrows in boxed region) and extend into the dentin (arrowheads). d, Peripherin fibers (red) extend to, but do not enter the odontoblast layer (boundary marked by arrowheads), whereas Trpm8GFP fibers (green) extend through and into the dentin (arrows). Yoshio Takashima et al. J. Neurosci. 2007;27:14147-14157 ©2007 by Society for Neuroscience