Developmental changes in Scn1a expression and susceptibility to hyperthermia-induced seizures. Developmental changes in Scn1a expression and susceptibility.

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Developmental changes in Scn1a expression and susceptibility to hyperthermia-induced seizures. Developmental changes in Scn1a expression and susceptibility to hyperthermia-induced seizures. A, Scn1a (red) and Scn3a (blue) mRNA quantification was expressed as a percentage of the maximum level, at different postnatal ages, 1–10 weeks, in the brain of F344/NSlc (triangle) and Hiss (rectangle) rats. Error bars indicate mean ± SE. *p < 0.05 for each age versus 1 week by ANOVA. B, Nav1.1 protein levels in the hippocampus of F344/NSlc (blue) and Hiss (red) rats at 1 and 5 weeks of age. The expression level was normalized against β-actin. *p < 0.05 and **p < 0.01 for 1 week versus 5 weeks by Student's t test. C, Quantitative analysis of the number of rats developing clonic seizures induced by hyperthermia in hot water (left) and extended convulsive seizures after taking them out of the water (right), at different postnatal ages 1–10 weeks, for F344/NSlc (top) and Hiss (bottom) rats. The numbers of rats are indicated in parentheses. *p < 0.01 versus F344/NSlc. Tomoji Mashimo et al. J. Neurosci. 2010;30:5744-5753 ©2010 by Society for Neuroscience