Variability of plasma aprotinin concentrations in pediatric patients undergoing cardiac surgery William C Oliver, MD, David N Fass, PhD, Gregory A Nuttall,

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Presentation transcript:

Variability of plasma aprotinin concentrations in pediatric patients undergoing cardiac surgery William C Oliver, MD, David N Fass, PhD, Gregory A Nuttall, MD, Joseph A Dearani, MD, Lisa M Schrader, MT, Darrell R Schroeder, MS, Mark H Ereth, MD, Francisco J Puga, MD The Journal of Thoracic and Cardiovascular Surgery Volume 127, Issue 6, Pages 1670-1677 (June 2004) DOI: 10.1016/j.jtcvs.2003.10.029

Figure 1 Plasma aprotinin concentrations determined for each patient at the following time intervals: (1) baseline (before aprotinin administration); (2) 5 minutes after aprotinin bolus; (3) 5 minutes after initiation of CPB; (4) 30 minutes during CPB; (5) 60 minutes during CPB; (6) discontinuation of aprotinin infusion; (7) 1 hour after aprotinin infusion was discontinued; and (8) 4 hours after permanent separation from CPB. Aprotinin was administered as a 25,000 KIU/kg bolus, 35,000 KIU/kg priming component, and 12,500 KIU · kg−1 · h−1 continuous infusion. One patient received full dose (280 mg bolus, 280 mg prime, and 70 mg/h continuous infusion), and 2 patients received half dose (140 mg bolus, 140 mg prime, and 35 mg/h continuous infusion). All of these patients weighed more than 40 kg. *Significant difference across weight groups (P < .05, 1-way analysis of variance). CPB, Cardiopulmonary bypass; KIU, kallikrein-inhibiting unit. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1670-1677DOI: (10.1016/j.jtcvs.2003.10.029)

Figure 2 Plasma aprotinin concentrations 5 minutes after the bolus of aprotinin according to weight. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1670-1677DOI: (10.1016/j.jtcvs.2003.10.029)

Figure 3 Plasma aprotinin concentrations 5 minutes after the initiation of CPB according to weight. The Journal of Thoracic and Cardiovascular Surgery 2004 127, 1670-1677DOI: (10.1016/j.jtcvs.2003.10.029)