Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems

Slides:



Advertisements
Similar presentations
Membrane Modulates Affinity for Calcium Ion to Create an Apparent Cooperative Binding Response by Annexin a5 Jacob W. Gauer, Kristofer J. Knutson, Samantha.
Advertisements

Creep Function of a Single Living Cell Nicolas Desprat, Alain Richert, Jacqueline Simeon, Atef Asnacios Biophysical Journal Volume 88, Issue 3, Pages
How Do Thermophilic Proteins and Proteomes Withstand High Temperature? Lucas Sawle, Kingshuk Ghosh Biophysical Journal Volume 101, Issue 1, Pages
Mechanical Stability and Reversible Fracture of Vault Particles Aida Llauró, Pablo Guerra, Nerea Irigoyen, José F. Rodríguez, Núria Verdaguer, Pedro J.
On the Thermodynamic Efficiency of Ca2+-ATPase Molecular Machines Anders Lervik, Fernando Bresme, Signe Kjelstrup, J. Miguel Rubí Biophysical Journal Volume.
Analysis of Kinetic Intermediates in Single-Particle Dwell-Time Distributions Daniel L. Floyd, Stephen C. Harrison, Antoine M. van Oijen Biophysical Journal.
Counter-Intuitive Stochastic Behavior of Simple Gene Circuits with Negative Feedback Tatiana T. Marquez-Lago, Jörg Stelling Biophysical Journal Volume.
Kinetic Properties of the Cardiac L-Type Ca2+ Channel and Its Role in Myocyte Electrophysiology: A Theoretical Investigation Gregory M. Faber, Jonathan.
Inhibitor Binding Increases the Mechanical Stability of Staphylococcal Nuclease Chien-Chung Wang, Tian-Yow Tsong, Yau-Heiu Hsu, Piotr E. Marszalek Biophysical.
Liposomes, Disks, and Spherical Micelles: Aggregate Structure in Mixtures of Gel Phase Phosphatidylcholines and Poly(Ethylene Glycol)-Phospholipids Markus.
Calcium Involvement in Regulation of Neuronal Bursting in Disinhibited Neuronal Networks: Insights from Calcium Studies in a Spherical Cell Model Pawel.
Structure and Dynamics of ER: Minimal Networks and Biophysical Constraints Congping Lin, Yiwei Zhang, Imogen Sparkes, Peter Ashwin Biophysical Journal.
The Dynamics and Mechanics of Endothelial Cell Spreading Cynthia A. Reinhart-King, Micah Dembo, Daniel A. Hammer Biophysical Journal Volume 89, Issue 1,
Calibration of Optical Tweezers for In Vivo Force Measurements: How do Different Approaches Compare? Yonggun Jun, Suvranta K. Tripathy, Babu R.J. Narayanareddy,
Tryptophan-Lipid Interactions in Membrane Protein Folding Probed by Ultraviolet Resonance Raman and Fluorescence Spectroscopy Katheryn M. Sanchez, Guipeun.
Large Uptake of Titania and Iron Oxide Nanoparticles in the Nucleus of Lung Epithelial Cells as Measured by Raman Imaging and Multivariate Classification.
Elucidating the Locking Mechanism of Peptides onto Growing Amyloid Fibrils through Transition Path Sampling Marieke Schor, Jocelyne Vreede, Peter G. Bolhuis.
Phase Resetting Curves Allow for Simple and Accurate Prediction of Robust N:1 Phase Locking for Strongly Coupled Neural Oscillators Carmen C. Canavier,
Quantitation of Malaria Parasite-Erythrocyte Cell-Cell Interactions Using Optical Tweezers Alex J. Crick, Michel Theron, Teresa Tiffert, Virgilio L. Lew,
Connexin Mutations in Skin Disease and Hearing Loss David P. Kelsell, Wei-Li Di, Mark J. Houseman The American Journal of Human Genetics Volume 68, Issue.
Molecular Model of a Cell Plasma Membrane With an Asymmetric Multicomponent Composition: Water Permeation and Ion Effects Robert Vácha, Max L. Berkowitz,
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Attraction of Rotors to the Pulmonary Veins in Paroxysmal Atrial Fibrillation: A Modeling Study Conrado J. Calvo, Makarand Deo, Sharon Zlochiver, José.
Is the Cross-Bridge Stiffness Proportional to Tension during Muscle Fiber Activation? Barbara Colombini, Marta Nocella, M. Angela Bagni, Peter J. Griffiths,
A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics Dmitry A. Fedosov, Bruce Caswell, George Em Karniadakis Biophysical Journal.
Yield Strength of Human Erythrocyte Membranes to Impulsive Stretching Fenfang Li, Chon U Chan, Claus Dieter Ohl Biophysical Journal Volume 105, Issue 4,
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
X-Ray Absorption Spectroscopy of Dinuclear Metallohydrolases David L. Tierney, Gerhard Schenk Biophysical Journal Volume 107, Issue 6, Pages
Location, Structure, and Dynamics of the Synthetic Cannabinoid Ligand CP-55,940 in Lipid Bilayers Tomohiro Kimura, Kejun Cheng, Kenner C. Rice, Klaus Gawrisch.
The Nuclear Pore Complex Mystery and Anomalous Diffusion in Reversible Gels Thomas Bickel, Robijn Bruinsma Biophysical Journal Volume 83, Issue 6, Pages.
Cytoskeletal Polymer Networks: Viscoelastic Properties are Determined by the Microscopic Interaction Potential of Cross-links O. Lieleg, K.M. Schmoller,
Contrast Inversion in the Epifluorescence of Cholesterol-Phospholipid Monolayers T.M. Okonogi, H.M. McConnell Biophysical Journal Volume 86, Issue 2, Pages.
A Hydrodynamic Model for Hindered Diffusion of Proteins and Micelles in Hydrogels Ronald J. Phillips Biophysical Journal Volume 79, Issue 6, Pages
Photochemical Reaction Dynamics of the Primary Event of Vision Studied by Means of a Hybrid Molecular Simulation Shigehiko Hayashi, Emad Tajkhorshid, Klaus.
Cross-Correlated TIRF/AFM Reveals Asymmetric Distribution of Force-Generating Heads along Self-Assembled, “Synthetic” Myosin Filaments André E.X. Brown,
Lever-Arm Mechanics of Processive Myosins Yujie Sun, Yale E. Goldman Biophysical Journal Volume 101, Issue 1, Pages 1-11 (July 2011) DOI: /j.bpj
Mesoscale Simulation of Blood Flow in Small Vessels Prosenjit Bagchi Biophysical Journal Volume 92, Issue 6, Pages (March 2007) DOI: /biophysj
Capsaicin Interaction with TRPV1 Channels in a Lipid Bilayer: Molecular Dynamics Simulation Sonya M. Hanson, Simon Newstead, Kenton J. Swartz, Mark S.P.
The Importance of the Hook Region of the Cochlea for Bone-Conduction Hearing Namkeun Kim, Charles R. Steele, Sunil Puria Biophysical Journal Volume 107,
The Interrelations among Stochastic Pacing, Stability, and Memory in the Heart Hila Dvir, Sharon Zlochiver Biophysical Journal Volume 107, Issue 4, Pages.
Cell Traction Forces Direct Fibronectin Matrix Assembly Christopher A. Lemmon, Christopher S. Chen, Lewis H. Romer Biophysical Journal Volume 96, Issue.
Quantifying the Rheological and Hemodynamic Characteristics of Sickle Cell Anemia Huan Lei, George Em Karniadakis Biophysical Journal Volume 102, Issue.
Increasing Membrane Tension Decreases Miscibility Temperatures; an Experimental Demonstration via Micropipette Aspiration Thomas Portet, Sharona E. Gordon,
IGERS: Inferring Gibbs Energy Changes of Biochemical Reactions from Reaction Similarities Kristian Rother, Sabrina Hoffmann, Sascha Bulik, Andreas Hoppe,
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Effects of Macromolecular Crowding on the Structure of a Protein Complex: A Small- Angle Scattering Study of Superoxide Dismutase Ajith Rajapaksha, Christopher.
How surgeons can find information online? Martin Hewitt International Journal of Surgery Volume 5, Issue 6, Pages (December 2007) DOI: /j.ijsu
2002 Air Medical Transport Industry Awards Air Medical Journal Volume 22, Issue 2, Pages (March 2003) DOI: /S X(03) Copyright.
Agarose-Dextran Gels as Synthetic Analogs of Glomerular Basement Membrane: Water Permeability Jeffrey A. White, William M. Deen Biophysical Journal Volume.
Phospholipid-Cholesterol Bilayers under Osmotic Stress Emma Sparr, Linda Hallin, Natalia Markova, Håkan Wennerström Biophysical Journal Volume 83, Issue.
Nonlinear Poisson Equation for Heterogeneous Media Langhua Hu, Guo-Wei Wei Biophysical Journal Volume 103, Issue 4, Pages (August 2012) DOI: /j.bpj
Direct Measurements of the Mechanical Stability of Zinc-Thiolate Bonds in Rubredoxin by Single-Molecule Atomic Force Microscopy Peng Zheng, Hongbin Li.
Different Effects of Trifluoroethanol and Glycerol on the Stability of Tropomyosin Helices and the Head-to-Tail Complex Fernando Corrêa, Chuck S. Farah.
Clamping Down on Tumor Proliferation
Volume 111, Issue 7, Pages (October 2016)
Volume 107, Issue 2, Pages (July 2014)
Plasmonic Electricity: A Digital form of Metal-Enhanced Fluorescence
SAXS versus FRET: A Matter of Heterogeneity?
Henry van den Bedem, Ellen Kuhl  Biophysical Journal 
Nanopore Sequencing: Forcing Improved Resolution
Volume 110, Issue 11, Pages (June 2016)
Unlocking Collagen Proteolysis with a Gentle Pull
Extruding Loops to Make Loopy Globules?
Volume 17, Issue 2, Pages (February 1950)
Conceptual Issues in Measuring the Burden of Skin Diseases
A Superresolution Census of RNA Polymerase
Huan-Xiang Zhou, Osman Bilsel  Biophysical Journal 
This Month in AJKD American Journal of Kidney Diseases
Michael Regnier, Yuanhua Cheng  Biophysical Journal 
Volume 4, Issue 3, Pages (March 2018)
Presentation transcript:

Systems Biophysics: Multiscale Biophysical Modeling of Organ Systems Andrew D. McCulloch  Biophysical Journal  Volume 110, Issue 5, Pages 1023-1027 (March 2016) DOI: 10.1016/j.bpj.2016.02.007 Copyright © 2016 Biophysical Society Terms and Conditions

Figure 1 (A–I) Multiscale models of cardiac electrophysiology and biomechanics can be combined to model cardiac electromechanical function in health and disease. To see this figure in color, go online. Biophysical Journal 2016 110, 1023-1027DOI: (10.1016/j.bpj.2016.02.007) Copyright © 2016 Biophysical Society Terms and Conditions