Lolium perenne peptides for treatment of grass pollen allergy: A randomized, double- blind, placebo-controlled clinical trial Mohamed H. Shamji, PhD,

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Figure 1. A) IgE binding to L perenne proteins and processed peptides by western blot (2.3 µg of proteins and peptides have been loaded on SDS gel) . B)

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Lolium perenne peptides for treatment of grass pollen allergy: A randomized, double- blind, placebo-controlled clinical trial Mohamed H. Shamji, PhD, FAAAAI, Jan Ceuppens, MD, Claus Bachert, MD, Peter Hellings, MD, Gaël Placier, PhD, Gaëtan Thirion, Nicolas Bovy, PhD, Stephen R. Durham, MD, FRCP, Jean Duchateau, MD, Thierry Legon, MBA, Sabine Pirotton, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 1, Pages 448-451 (January 2018) DOI: 10.1016/j.jaci.2017.09.013 Copyright © 2017 The Authors Terms and Conditions

Fig 1 A, IgE binding to L perenne proteins and processed peptides by using Western blotting (2.3 μg of proteins and peptides have been loaded on an SDS gel). B, Capacity of the L perenne proteins and LPPs to inhibit binding of specific IgE (sIgE) to pollen. C, Batch-to-batch reproducibility of LPPs. D and E, Ex vivo basophil responsiveness to L perenne proteins, LPPs, DnaK, and LPP/DnaK in patients with grass pollen allergy (n = 12) and nonallergic subjects (n = 12). The Wilcoxon rank test was used for comparison with corresponding concentration of LPPs. F-H, sIgE, sIgG4, and blocking antibody responses after subcutaneous LPPs, LPP/DnaK, or placebo. I and J, Number of well days and cumulative dose of LPP and LPP/DnaK. *P <.05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2018 141, 448-451DOI: (10.1016/j.jaci.2017.09.013) Copyright © 2017 The Authors Terms and Conditions

Fig E1 Journal of Allergy and Clinical Immunology 2018 141, 448-451DOI: (10.1016/j.jaci.2017.09.013) Copyright © 2017 The Authors Terms and Conditions

Fig E2 Journal of Allergy and Clinical Immunology 2018 141, 448-451DOI: (10.1016/j.jaci.2017.09.013) Copyright © 2017 The Authors Terms and Conditions

Fig E3 Journal of Allergy and Clinical Immunology 2018 141, 448-451DOI: (10.1016/j.jaci.2017.09.013) Copyright © 2017 The Authors Terms and Conditions

Fig E4 Journal of Allergy and Clinical Immunology 2018 141, 448-451DOI: (10.1016/j.jaci.2017.09.013) Copyright © 2017 The Authors Terms and Conditions