Christos Alexiou, Stephen M

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Presentation transcript:

Aortic root replacement in patients with Marfan’s syndrome: the Southampton experience  Christos Alexiou, Stephen M. Langley, Phillip Charlesworth, MBBS, Marcus P. Haw, Steven A. Livesey, James L. Monro  The Annals of Thoracic Surgery  Volume 72, Issue 5, Pages 1502-1507 (November 2001) DOI: 10.1016/S0003-4975(01)02993-9

Fig 1 Kaplan-Meier 10-year freedom from late valve-related events. Freedom from prosthetic valve endocarditis (PVE), thromboembolism (TE), bleeding, and from any of these events was 98.4% ± 1.6%, 88% ± 5.1%, 89.8% ± 4.8%, and 81.2% ± 6.1%, respectively. The Annals of Thoracic Surgery 2001 72, 1502-1507DOI: (10.1016/S0003-4975(01)02993-9)

Fig 2 Kaplan-Meier freedom 10-year from late aortic events for all patients was 86.3% ± 3.4%. For patients with chronic aneurysm it was 91.9% ± 6% and for those with a type A dissection 74.1% ± 11.7% (p = 0.02 on univariate and p = 0.01 on multivariate analysis). The Annals of Thoracic Surgery 2001 72, 1502-1507DOI: (10.1016/S0003-4975(01)02993-9)

Fig 3 Kaplan-Meier 10-year freedom from reoperation was 89.2% ± 3%. The Annals of Thoracic Surgery 2001 72, 1502-1507DOI: (10.1016/S0003-4975(01)02993-9)

Fig 4 Overall Kaplan-Meier 5-year and 10-year survival (continuous line), including operative mortality, was 85.5% ± 4.5% and 72.7% ± 6.5%, respectively. Survival free of life-threatening complications (thromboembolism, major bleeding, endocarditis, and aortic events) (dotted line) at 5 and 10 years was 80.5% ± 5.1% and 60% ± 7.6%, respectively. The Annals of Thoracic Surgery 2001 72, 1502-1507DOI: (10.1016/S0003-4975(01)02993-9)

Fig 5 Kaplan-Meier 10-year survival for the patients with chronic aneurysm (continuous line) was 79.5% ± 7.4% and for those with type A dissection (dotted line) 60% ± 12.1% (p = 0.4). The Annals of Thoracic Surgery 2001 72, 1502-1507DOI: (10.1016/S0003-4975(01)02993-9)