Fig. 7 LPS enhances cochlear TRPV1 expression and GTTR uptake in vivo.

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Fig. 7 LPS enhances cochlear TRPV1 expression and GTTR uptake in vivo. LPS enhances cochlear TRPV1 expression and GTTR uptake in vivo. (A) LPS enhanced TRPV1 expression in wild-type (WT) marginal cells compared to DPBS-treated wild-type mice. LPS did not enhance TRPV1 expression in marginal cells of Tlr4 KO mice. (B) LPS significantly enhanced TRPV1 immunofluorescence in marginal cells (MC) of wild-type, but not Tlr4 KO, mice (**P < 0.01; n ≥ 6). TRPV1 immunofluorescence in intra-strial (IS) and basal cells (BC), as well as spiral ligament fibrocytes (SL), was not significantly altered. (C) LPS significantly enhanced TRPV1 immunofluorescence in OHCs of wild-type, but not Tlr4 KO, mice (*P < 0.05; n ≥ 5). (D) LPS enhanced TRPV1 expression in the reticular lamina of wild-type mice compared to DPBS-treated wild-type mice. LPS did not enhance TRPV1 expression in the organ of Corti of Tlr4 KO mice. (E) Significantly increased Trpv1 mRNA expression in the cochleae of wild-type, but not in Tlr4 KO, cochleae following LPS exposure (*P < 0.05; n ≥ 5). (F) Significantly increased Trpv1 mRNA expression in the cochleae of wild-type, but not Trpv1 KO, cochleae following LPS exposure (**P < 0.01; n ≥ 3). (G) Intravenous LPS 24 hours before GTTR injection significantly increased OHC uptake of GTTR in wild-type mice (****P < 0.0001; n ≥ 3) but not in Trpv1 KO mice (H; n ≥ 3). Error bars, SD. Scale bars, 20 μm. Meiyan Jiang et al. Sci Adv 2019;5:eaaw1836 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).