Postulated impact of SLE on endothelial nitric oxide (NO) synthase activity and endothelial nitric oxide synthase (eNOS) uncoupling. Postulated impact.

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Postulated impact of SLE on endothelial nitric oxide (NO) synthase activity and endothelial nitric oxide synthase (eNOS) uncoupling. Postulated impact of SLE on endothelial nitric oxide (NO) synthase activity and endothelial nitric oxide synthase (eNOS) uncoupling. (A) In normal conditions, basal eNOS oxidises L-arginine to L-citrulline and produces NO. However, in the presence of components found in lupus serum, NAPDH oxidase is activated leading to reactive oxygen species and subsequent production of peroxynitrite. (B) Supplementation of low-dose L-sepiapterin in cell cultures raises intracellular BH4 levels leading to improvements in NO production in lupus serum cultured cells. Joy N Jones Buie et al. Lupus Sci Med 2019;6:e000294 ©2019 by Lupus Foundation of America