Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave,

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Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

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Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc, Angela Simpson, MD, PhD, Aida Semic-Jusufagic, MD, PhD, Clare S. Murray, MD, Iain Buchan, MD, PhD, Andrew Pickles, PhD, Adnan Custovic, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 3, Pages 575-583.e12 (September 2013) DOI: 10.1016/j.jaci.2013.05.041 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Characteristics of 5 wheeze classes: percentage of participants with reported wheezing according to either parentally reported or physician-confirmed wheeze (A), physician-confirmed wheeze only (B), and parentally reported wheeze only (C). The number of children in each class is denoted in parentheses. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Trajectories of atopy (A), sRaw (B), asthma treatment (C), and ICSs (D) over time for each of the wheeze classes. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Trajectories of severe exacerbations (A), hospital admissions (B), and unscheduled visits for asthma (C) over time for each of the wheeze classes. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Linear trajectory model based on parentally reported and physician-confirmed wheeze. Plates represent variables repeated over different measurements. Unshaded circles represent observed variables, and shaded circles represent unobserved or latent variables to be inferred. Because we used binary variables, the arrows in the figure represent a logistic regression model for these variables. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Prevalence of wheeze according to GP records and parental questionnaire information. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Plot showing change in BIC for the linear and quadratic change trajectory model when different numbers of latent classes are assumed. Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Nelson-Aalen cumulative hazard plots for time to first severe asthma exacerbation within the first 8 years of life (A), time to first severe asthma exacerbation after age 3 years (B), time to first asthma/wheeze-related hospital admission within the first 8 years of life (C), and time to first asthma/wheeze-related hospital admission after age 3 years (D). Journal of Allergy and Clinical Immunology 2013 132, 575-583.e12DOI: (10.1016/j.jaci.2013.05.041) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions