A B Supplemental Figure 1. Growth of secondary (left-leg) tumors and lack of change in body weight in a Lewis lung carcinoma mouse model after treatments.

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A B Supplemental Figure 1. Growth of secondary (left-leg) tumors and lack of change in body weight in a Lewis lung carcinoma mouse model after treatments of radiation and the IDO1 inhibitor INCB023843. (A) Growth curves for the secondary tumors from the mice in Figure 1, the second tumor was inoculated on day 5 (n=11/group). (B) No significant changes in body weight (weight at day 18 minus weight at day 10) were found after radiation or INCB023843 treatment (or both) (n=11/group). The experiments were repeated three times.

A B Plasma Kyn level (nM) * Kyn/Trp ratio (nM/µM) Plasma Supplemental Figure 2. Plasma Kyn levels and Kyn/Trp ratios increased after 12-Gy×3 radiation but was inhibited by the addition of an IDO1 inhibitor. (A) Plasma Kyn concentrations in mice (n= 3/group). (B) Kyn/Trp ratios from plasma in (A, n= 3/group). *P<0.05. The experiment were repeated two times.