Top left—H&E stain showing acute hepatitis with lobular disarray and associated lymphocytic inflammation, acidophil body formation (arrow) and bilirubinostasis.

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Top left—H&E stain showing acute hepatitis with lobular disarray and associated lymphocytic inflammation, acidophil body formation (arrow) and bilirubinostasis. Top left—H&E stain showing acute hepatitis with lobular disarray and associated lymphocytic inflammation, acidophil body formation (arrow) and bilirubinostasis. Top right—H&E stain showing features of chronic hepatitis in the context of chronic hepatitis B infection. There is a moderately dense portal infiltrate comprising predominantly lymphocytes, showing conspicuous interface activity (arrow). L, lobule; P, portal tract. Bottom right—H&E stain showing the classical changes of primary biliary cholangitis with a florid granulomatous inflammatory bile duct lesion. The residual damaged duct is seen in the centre of the image (arrow). Bottom left—H&E stain showing concentric fibrosis surrounding an inflamed bile duct, a typical change of primary sclerosing cholangitis. Alexander Boyd et al. Frontline Gastroenterol doi:10.1136/flgastro-2018-101139 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.