Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility Joop S.E Laven, Ph.D., Annemarie G.M.G.J.

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Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility Joop S.E Laven, Ph.D., Annemarie G.M.G.J Mulders, M.D., Dwi A Suryandari, M.Sc., Jörg Gromoll, Ph.D., Eberhard Nieschlag, M.D., Bart C.J.M Fauser, Ph.D., Manuela Simoni, Ph.D. Fertility and Sterility Volume 80, Issue 4, Pages 986-992 (October 2003) DOI: 10.1016/S0015-0282(03)01115-4

Figure 1 Distribution of the three possible FSH receptor genotypes at positions 307 (A) and 680 (B) in exon 10 of the FSH receptor gene among normogonadotropic anovulatory women and normo-ovulatory controls. The difference in distribution between anovulatory patients and normo-ovulatory controls was significant for both polymorphisms (P<.05 for position 307 and P<.05 for position 680). Laven. FSH receptor polymorphisms and anovulation.Fertil Steril 2003. Fertility and Sterility 2003 80, 986-992DOI: (10.1016/S0015-0282(03)01115-4)

Figure 2 The similarity in distribution of several FSH receptor genotypes among normogonadotropic anovulatory women and normo-ovulatory controls. Since the Ala307/Ser680–Thr307/Asn680 and Ala307/Asn680–Thr307/Ser680 genotype cannot be distinguished by the methods used, they are considered together and designated as Ala307/Ser680–Thr307/Asn680. Laven. FSH receptor polymorphisms and anovulation.Fertil Steril 2003. Fertility and Sterility 2003 80, 986-992DOI: (10.1016/S0015-0282(03)01115-4)

Figure 3 Distribution of the three possible FSH receptor genotypes at both positions 307 and 680 in exon 10 of the FSH receptor gene among women without the polycystic ovary syndrome (non-PCOS), women with PCOS (PCOS), and normo-ovulatory controls. The distribution of both polymorphisms significantly differed between women with PCOS and those without PCOS on one hand and controls on the other hand. Laven. FSH receptor polymorphisms and anovulation.Fertil Steril 2003. Fertility and Sterility 2003 80, 986-992DOI: (10.1016/S0015-0282(03)01115-4)