Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice

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Presentation transcript:

Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice P.O. Ribeiro, A.M. Valentim, P. Rodrigues, I.A. Olsson, L.M. Antunes British Journal of Anaesthesia Volume 108, Issue 5, Pages 807-814 (May 2012) DOI: 10.1093/bja/aes003 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Timeline of the behaviour tests. British Journal of Anaesthesia 2012 108, 807-814DOI: (10.1093/bja/aes003) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Number of trials necessary to complete the T-maze task at 28 h, 1 week, and 2 weeks after i.p. injection in different groups (n=8). Data are presented as box and whisker plots showing the median, inter-quartile range, and 5th and 95th percentiles. ○=outlier and *=extreme value. British Journal of Anaesthesia 2012 108, 807-814DOI: (10.1093/bja/aes003) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 Latency time to turn (latency) and completely descend the vertical pole (end pole) in seconds, 4 h after anesthesia (n=8); 120 s was attributed to the animals that fell. *P≤0.021 and **P≤0.028. Data are presented as box and whisker plots showing the median, inter-quartile range, and 5th and 95th percentiles. ○=outlier. British Journal of Anaesthesia 2012 108, 807-814DOI: (10.1093/bja/aes003) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Speed in the open-field test induced by the different treatment groups (n=8) during 20 min, 24 h post-anaesthesia. *P=0.033 compared with the control group. Mean (sd) shown. British Journal of Anaesthesia 2012 108, 807-814DOI: (10.1093/bja/aes003) Copyright © 2012 The Author(s) Terms and Conditions

Fig 5 (a) The number of dead cells (HE), (b) number of caspase-3 activation positive profiles (apoptosis), and (c) ratio of the number of positive BDNF expression/negative BDNF expression (mm2) in the retrosplenial cortex, visual cortex, pyramidal cell layer of the CA1 and CA3 areas of the hippocampus, and in the granular layer of the dentate gyrus, 3 h after anaesthesia in different groups (n=5). Mean (sd) shown. No significant difference between groups was observed. British Journal of Anaesthesia 2012 108, 807-814DOI: (10.1093/bja/aes003) Copyright © 2012 The Author(s) Terms and Conditions