Interpretation of subgroup analyses in systematic reviews: A tutorial

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Presentation transcript:

Interpretation of subgroup analyses in systematic reviews: A tutorial Marty Richardson, Paul Garner, Sarah Donegan Clinical Epidemiology and Global Health Volume 7, Issue 2, Pages 192-198 (June 2019) DOI: 10.1016/j.cegh.2018.05.005 Copyright © 2018 Terms and Conditions

Fig. 1 Subgroup analysis 1: Statistically significant, quantitative subgroup effect. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions

Fig. 2 Subgroup analysis 2: Statistically significant, qualitative subgroup effect, substantial unexplained heterogeneity. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions

Fig. 3 Subgroup analysis 3: No subgroup effect. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions

Fig. 4 Subgroup analysis 4: No subgroup effect, moderate unexplained heterogeneity. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions

Fig. 5 Subgroup analysis 5: Statistically significant subgroup effect, uneven covariate distribution. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions

Fig. 6 AL6 versus AQ+SP; total treatment failure at day 28. N.B.: The review did not present the test for subgroup differences in their review, but this has been presented here to aid the reader’s interpretation. Source: Artemisinin-based combination therapy for treating uncomplicated malaria, published by Sinclair et al.6; Analysis 11.1. Clinical Epidemiology and Global Health 2019 7, 192-198DOI: (10.1016/j.cegh.2018.05.005) Copyright © 2018 Terms and Conditions