Nitroglycerin as a nitric oxide donor accelerates lipid peroxidation but preserves ventricular function in a canine model of orthotopic heart transplantation

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Nitroglycerin as a nitric oxide donor accelerates lipid peroxidation but preserves ventricular function in a canine model of orthotopic heart transplantation Yoshihisa Tanoue, MD, Shigeki Morita, MD, Yoshie Ochiai, MD, Naho Haraguchi, MD, Ryuji Tominaga, MD, Yoshito Kawachi, MD, Hisataka Yasui, MD The Journal of Thoracic and Cardiovascular Surgery Volume 118, Issue 3, Pages 547-556 (September 1999) DOI: 10.1016/S0022-5223(99)70195-9 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 A, Cardiopulmonary bypass for the assessment of coronary endothelial function. The coronary vessels were isolated from the systemic circuit by crossclamping the ascending aorta and were perfused with oxygenated blood through the side arm of the arterial line. Acetylcholine and sodium nitroprusside were infused from this side arm for the assessment of coronary endothelial function. ACh, Acetylcholine; SNP, sodium nitroprusside; RV, right ventricular; LV, left ventricular. B, Right heart bypass for the assessment of left ventricular function. To measure the left ventricular pressure–volume loop, a catheter-tip micromanometer and conductance catheter were inserted into the left ventricle. Right heart bypass was instituted to control the left ventricular venous return and to completely decompress the right ventricle, thereby eliminating parallel conductance variation. The Journal of Thoracic and Cardiovascular Surgery 1999 118, 547-556DOI: (10.1016/S0022-5223(99)70195-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 The changes of coronary vascular resistance at 15, 30, 60, and 150 minutes after reperfusion in group NTG and group C. Two-factor analysis of variance with repeated measures on 1 factor showed that the changes of coronary vascular resistance were marginally different between the 2 groups (P = .08). Data are presented as mean ± standard deviation. The Journal of Thoracic and Cardiovascular Surgery 1999 118, 547-556DOI: (10.1016/S0022-5223(99)70195-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 Percent endothelium-dependent coronary relaxation induced by acetylcholine and percent endothelium-independent coronary relaxation induced by sodium nitroprusside in group NTG and group C. The 2 groups were similar with respect to percent endothelium-dependent coronary relaxation induced by acetylcholine and percent endothelium-independent coronary relaxation induced by sodium nitroprusside. ACh, Acetylcholine; SNP, sodium nitroprusside. Data are presented as mean ± standard deviation. The Journal of Thoracic and Cardiovascular Surgery 1999 118, 547-556DOI: (10.1016/S0022-5223(99)70195-9) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 4 Serum CK-MB levels (A), serum lipid peroxide levels (B), and the total plasma concentrations of nitrite and nitrate (C) before reperfusion and at 15, 30, 60, and 150 minutes after reperfusion in group NTG and group C. Serum CK-MB levels in group NTG tended to be higher than those in group C, although the differences did not reach statistical significance. Two-factor analysis of variance with repeated measures on 1 factor showed that serum lipid peroxide levels after reperfusion in group NTG were significantly higher than those in group C (P = .02) and that the total plasma concentrations of nitrite and nitrate after reperfusion in group NTG were significantly higher than those in group C (P = .001). CK-MB, Creatine kinase-MB; LPO, lipid peroxide; NO2+NO3, total plasma concentrations of nitrite and nitrate. Data are presented as mean ± standard deviation. The Journal of Thoracic and Cardiovascular Surgery 1999 118, 547-556DOI: (10.1016/S0022-5223(99)70195-9) Copyright © 1999 Mosby, Inc. Terms and Conditions