KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis Elisabet Johansson, PhD, Jocelyn.

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Presentation transcript:

KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis Elisabet Johansson, PhD, Jocelyn M. Biagini Myers, PhD, Lisa J. Martin, PhD, Hua He, MS, Valentina Pilipenko, PhD, Tesfaye Mersha, PhD, Matthew Weirauch, PhD, Nathan Salomonis, PhD, Patrick Ryan, PhD, Grace K. LeMasters, PhD, David I. Bernstein, MD, James Lockey, MD, Gurjit K. Khurana Hershey, MD, PhD Journal of Allergy and Clinical Immunology Volume 140, Issue 2, Pages 595-598.e5 (August 2017) DOI: 10.1016/j.jaci.2017.02.003 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Associations between tagging KIF3A SNPs and allergic phenotypes compared with nonallergic controls. Gray dotted lines: Significance at P = .05. Blue dotted lines: Significance after Bonferroni correction. B, Percentage of all children with asthma in the GCPCR cohort who also had comorbid eczema (red line) or AR (blue line), as a function of the number of KIF3A rs2299007 minor alleles. OR, Odds ratio. Journal of Allergy and Clinical Immunology 2017 140, 595-598.e5DOI: (10.1016/j.jaci.2017.02.003) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Venn diagram showing composite phenotypes in the GCPCR cohort and sample sizes for each phenotype. Because some children in the GCPCR cohort lacked a definitive diagnosis for 1 or 2 diseases, they could not be placed in the Venn diagram. Therefore, the total number is slightly lower than that indicated in Table E1. Journal of Allergy and Clinical Immunology 2017 140, 595-598.e5DOI: (10.1016/j.jaci.2017.02.003) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 R2 plot of LD between KIF3A SNPs used in the genotyping of GCPCR and CCAAPS. R2 values were calculated for the HapMap CEU population. Journal of Allergy and Clinical Immunology 2017 140, 595-598.e5DOI: (10.1016/j.jaci.2017.02.003) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions