Double-immunofluorescence labeling of Arg-1 in WT (A) and IL-10−/− (C) mice at 3 (i) and 7 (ii) days postinjury (dpi). Double-immunofluorescence labeling.

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Double-immunofluorescence labeling of Arg-1 in WT (A) and IL-10−/− (C) mice at 3 (i) and 7 (ii) days postinjury (dpi). Double-immunofluorescence labeling of Arg-1 in WT (A) and IL-10−/− (C) mice at 3 (i) and 7 (ii) days postinjury (dpi). The sections are double labeled for the macrophage marker CD11b (B, D). Note that Arg-1 is expressed in some CD11b+ macrophages at 3 dpi in WT nerves (Ai) and this is decreased in IL-10−/− nerves at 3 dpi (Ci). No Arg-1 staining is seen at 7 dpi in either genotype (Aii, Cii); note the abundance of CD11b+ macrophages in these regions. Scale bar, 100 μm. E, Fold increase in the expression of 10 chemokines and cytokines that were statistically significantly increased in IL-10-null nerves compared with WT nerves at 24 h after crush injury detected with a PCR array screen. The horizontal bar represents level in injured WT nerves. n = 3–4; p < 0.05 for all values shown. Il6, Interleukin 6; Ltb, lymphotoxin β; Thpo, thrombopoietin. Bruno Siqueira Mietto et al. J. Neurosci. 2015;35:16431-16442 ©2015 by Society for Neuroscience